Evidence map›Paper›PMID 31010814›Full record

ArticleInfection and immunity2019

Infection of Primary Human Alveolar Macrophages Alters Staphylococcus aureus Toxin Production and Activity.

Katelynn R Brann, Marissa S Fullerton, Frances I Onyilagha, Andrew A Prince, Richard C Kurten, Joseph S Rom, Jon S Blevins, Mark S Smeltzer, Daniel E Voth

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Interaction BetweenCurrent pharmaceutical biotechnology · 2026
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  3. Intracellular survival ofVirulence · 2025
    Review
  4. Review
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  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. The Impacts ofInfection and immunity · 2020
    Article
  14. Cathepsins in Bacteria-Macrophage Interaction: Defenders or Victims of Circumstance?Frontiers in cellular and infection microbiology · 2020
    Review
  15. The Role of Macrophages inFrontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Katelynn R BrannDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Marissa S FullertonDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Frances I OnyilaghaDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Andrew A PrinceDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Richard C KurtenDepartment of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Joseph S RomDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Jon S BlevinsDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Mark S SmeltzerDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Daniel E VothDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA dvoth@uams.edu.
University of Arkansas for Medical Sciences · US

Funding

Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Impact of Staphylococcus aureus in osteomyelitis and bone physiologyR01AI119380 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI BEENKEN, KAREN E., SMELTZER, MARK S · 2015 to 2025
$4.1M
A Novel Human Lung Infection Platform to Define Staphylococcus aureus Virulence DeterminantsR21AI142056 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI VOTH, DANIEL E · 2019 to 2020
$404k
NCATS NIH HHS UL1 TR000039NCATS NIH HHS UL1 TR003107NIAID NIH HHS R01 AI119380NIAID NIH HHS R21 AI142056NIGMS NIH HHS P20 GM103625
6 · The paper itself

Abstract

Pulmonary pathogens encounter numerous insults, including phagocytic cells designed to degrade bacteria, while establishing infection in the human lung.

Indexed as

Staphylococcal InfectionsAnti-Bacterial AgentsBacterial ToxinsExotoxinsHumansLeukocidinsLungMacrophages, AlveolarPhagosomesStaphylococcus aureusVirulence FactorsAnti-Bacterial AgentsBacterial ToxinsExotoxinsLeukocidinsPanton-Valentine leukocidinVirulence Factorshost-pathogenintracellularmacrophagepulmonaryStaphylococcus aureustoxin

Identifiers

PMID31010814
PMCPMC6589068
OpenAlexW2940171226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.