Evidence map›Paper›PMID 31010708›Full record

ReviewClinical oncology (Royal College of Radiologists (Great Britain))2019

Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken.

M-C Vozenin, J H Hendry, C L Limoli

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical oncology (Royal College of Radiologists (Great Britain)), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Deciphering Ultra-High Dose Rate Irradiation withAntioxidants (Basel, Switzerland) · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Development and application ofPhysics and imaging in radiation oncology · 2026
    Article
  19. Investigating the FLASH Effect in a Rat Brain Organotypic Model With a Novel High-Energy Electron Beam.International journal of radiation oncology, biology, physics · 2026
    Article
  20. Article

135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

M-C VozeninLaboratory of Radiation Oncology/CHUV, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Department of Radiation Oncology/Department of Oncology/CHUV, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: marie-catherine.vozenin@chuv.ch.
J H HendryDepartment of Medical Physics and Engineering, Christie Hospital, Manchester, UK.
C L LimoliDepartment of Radiation Oncology, University of California, Irvine, California, USA.

Funding

Mechanisms underlying radiation-and chemotherapy induced cognitive impairment.R01NS089575 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2015 to 2020
$2.8M
NINDS NIH HHS R01 NS089575
6 · The paper itself

Abstract

FLASH radiotherapy (FLASH-RT) is a technology that could modify the way radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of radiotherapy at dose rates several orders of magnitude higher than those currently used in routine clinical practice. This very short time of exposure leads to the striking observation of relative protection of normal tissues that are exposed to FLASH-RT as compared with conventional dose rate radiotherapy. Here we summarise the current knowledge about the FLASH effect and provide a synthesis of the observations that have been reported on various experimental animal models (mice, zebrafish, pig, cats), various organs (lung, gut, brain, skin) and by various groups across 40 years of research. We also propose possible mechanisms for the FLASH effect, as well as possible paths for clinical application.

Indexed as

HumansRadiotherapyRadiotherapy DosageDifferential effectFLASH radiotherapynormal tissue protectionoxygen

Identifiers

PMID31010708
PMCPMC6850216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.