ArticleOral oncology2019
Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography.
Article in Oral oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Effects of surgical resection on tissue autofluorescence lifetime signatures in head and neck cancer: implications for intraoperative tumor margin assessment.Journal of biomedical optics · 2026Article
- Review
- Optical Coherence Tomography (OCT) Evaluation of Thermal Tissue Alterations After Diode Laser Excision of Oral Leukoplakia (OL).Dentistry journal · 2026Article
- Diagnostic accuracy of optical coherence tomography for early oral cancer detection: A systematic review.Imaging science in dentistry · 2026Review
- Optical Coherence Tomography for Invasive Oral Squamous Cell Carcinoma: Diagnostic Accuracy and Grade- and Subsite-Associated Imaging Features.Journal of clinical medicine · 2026Article
- Assessment and interpretation of the status of surgical margins following resective surgery for head and neck squamous cancer: a narrative review.World journal of surgical oncology · 2025Review
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- Quantitative assessment of biomechanical changes in oral lesions at different cancerous stages using optical coherence elastography.Quantitative imaging in medicine and surgery · 2025Article
- Advancing Non-Invasive Diagnosis of Oral Epithelial Dysplasia: Comparative Insights from In Vivo Optical Coherence Tomography and Histopathology.Journal of clinical medicine · 2025Article
- Critical review of OCT in clinical practice for the assessment of oral lesions.Frontiers in oncology · 2025Review
- Oral Mucosa Capillaroscopy: A Narrative Review.Cancers · 2024Review
- Application of Targeted Optical Coherence Tomography in Oral Cancer: A Cross-Sectional Preliminary Study.Diagnostics (Basel, Switzerland) · 2024Article
- Enhancing Oral Cancer Detection: A Systematic Review of the Diagnostic Accuracy and Future Integration of Optical Coherence Tomography with Artificial Intelligence.Journal of clinical medicine · 2024Review
- Discrimination of healthy oral tissue from oral cancer based on the mean grey value determined by optical coherence tomography.BMC oral health · 2024Article
- Imaging Biomarkers of Oral Dysplasia and Carcinoma Measured with In Vivo Endoscopic Optical Coherence Tomography.Cancers · 2024Article
- A Prospective Double-Blinded Comparison of Reflectance Confocal Microscopy with Conventional Histopathology for In Vivo Assessment in Oral Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Viscoelasticity quantification of cancerous tongue using intraoral optical coherence elastography: a preliminary study.Biomedical optics express · 2024Article
- Intraoperative Techniques That Define the Mucosal Margins of Oral Cancer In-Vivo: A Systematic Review.Cancers · 2024Review
- State of the Art in the Diagnosis and Assessment of Oral Malignant and Potentially Malignant Disorders: Present Insights and Future Outlook-An Overview.Bioengineering (Basel, Switzerland) · 2024Review
- Early Detection of Oral Potentially Malignant Disorders: A Review on Prospective Screening Methods with Regard to Global Challenges.Journal of maxillofacial and oral surgery · 2024Review
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Authors and funding
13 authors.
Funding
Abstract
objectivesSurgical margin status is a significant determinant of treatment outcome in oral cancer. Negative surgical margins can decrease the loco-regional recurrence by five-fold. The current standard of care of intraoperative clinical examination supplemented by histological frozen section, can result in a risk of positive margins from 5 to 17 percent. In this study, we attempted to assess the utility of intraoperative optical coherence tomography (OCT) imaging with automated diagnostic algorithm to improve on the current method of clinical evaluation of surgical margin in oral cancer. MATERIALS AND
methodsWe have used a modified handheld OCT device with automated algorithm based diagnostic platform for imaging. Intraoperatively, images of 125 sites were captured from multiple zones around the tumor of oral cancer patients (n = 14) and compared with the clinical and pathologic diagnosis.
resultsOCT showed sensitivity and specificity of 100%, equivalent to histological diagnosis (kappa, ĸ = 0.922), in detection of malignancy within tumor and tumor margin areas. In comparison, for dysplastic lesions, OCT-based detection showed a sensitivity of 92.5% and specificity of 68.8% and a moderate concordance with histopathology diagnosis (ĸ = 0.59). Additionally, the OCT scores could significantly differentiate squamous cell carcinoma (SCC) from dysplastic lesions (mild/moderate/severe; p ≤ 0.005) as well as the latter from the non-dysplastic lesions (p ≤ 0.05).
conclusionThe current challenges associated with clinical examination-based margin assessment could be improved with intra-operative OCT imaging. OCT is capable of identifying microscopic tumor at the surgical margins and demonstrated the feasibility of mapping of field cancerization around the tumor.
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