Evidence map›Paper›PMID 31010439›Full record

ArticleLipids in health and disease2019

ATP-binding cassette sub-family a member1 gene mutation improves lipid metabolic abnormalities in diabetes mellitus.

Huili Yan, Lei Cheng, Ruoshuang Jia, Huiqian Yao, Hongxia Wu, Yaqian Shen, Ying Zhang, Panpan Hao, Zhongwen Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Genes · 2022
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Huili YanDepartment of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, and Department of Cardiology, Shandong University Qilu Hospital, Jinan, Shandong, China.
Lei ChengSchool of Basic Medical Sciences of Shandong University, Jinan, Shandong, China.
Ruoshuang JiaSchool of Basic Medical Sciences of Shandong University, Jinan, Shandong, China.
Huiqian YaoDepartment of Surgery, Juye Coalfield Central Hospital, Heze, Shandong, China.
Hongxia WuDepartment of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.
Yaqian ShenSchool of Basic Medical Sciences of Shandong University, Jinan, Shandong, China.
Ying ZhangSchool of Basic Medical Sciences of Shandong University, Jinan, Shandong, China.
Panpan HaoDepartment of Cardiology, Shandong University Qilu Hospital, Jinan, Shandong, China. panda.how@126.com.
Zhongwen ZhangDepartment of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China. zhangzhongwen521@126.com.ORCID http://orcid.org/0000-0001-6702-1357
Shandong University · CNQilu Hospital of Shandong University · CN

Funding

National Natural Science Foundation of China 81400284Natural Science Foundation of Shandong Province ZR2016HQ26Shandong Provincial Finance Department 2018GSF118176 to Z.W.Z. and 2018GSF118234 to P.P.H
6 · The paper itself

Abstract

backgroundPatients with diabetes mellitus were often accompanied with hyperlipidemia. ATP-binding cassette sub-family A member1 (ABCA1) promotes the efflux of lipids and thereby mediates the metabolism of cholesterol. The aim of our study was to determine the associations of ABCA1 gene polymorphisms with the risks of diabetes mellitus and dyslipidemia in diabetic patients.

methodsWe retrieved literature about the relationship between ABCA1 gene polymorphisms (C69T and R230C) and the risk of diabetes through PubMed, Web of Science, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Cochrane database. Weighted mean difference (WMD) and odds ratio (OR) were used to compare continuous and dichotomous variables, respectively, accompanied by their 95% confidence interval (CI).

resultsA total of 1746 diabetic patients and 1292 non-diabetic controls were enrolled. All subjects were Caucasians. ABCA1 R230C T allele was significantly associated with reduced the risk of diabetes (OR = 0.75, 95% CI = 0.57-0.98, P = 0.04). There was no association of ABCA1 C69T gene polymorphisms with the risk of diabetes. However, subgroup analyses showed that the ABCA1 C69T gene mutation significantly reduced the risk of hypertriglyceridemia in diabetic patients as compared with that in non-diabetic subjects (dominant model: WMD =0.66, 95% CI = 0.52-0.8, P < 0.0001; recessive model: WMD = 0.47, 95%CI = 0.11-0.83, P = 0.01).

conclusionsABCA1 R230C T allele gene mutation is a protective in decreasing the risk of diabetes in Caucasians and ABCA1 C69T gene mutation markedly influences the level of lipid metabolism in diabetic patients.

Indexed as

ATP Binding Cassette Transporter 1Diabetes MellitusGenes, DominantGenetic Association StudiesGenetic Predisposition to DiseaseHumansLipid MetabolismMiddle AgedMutationPolymorphism, Single NucleotidePublication BiasRisk FactorsATP Binding Cassette Transporter 1ATP-binding cassette sub-family a member1Diabetes mellitusHypertriglyceridemiaTriglyceride

Identifiers

PMID31010439
PMCPMC6477720
OpenAlexW2945834301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.