ArticlePlant signaling & behavior2019
Tomato SlWRKY3 acts as a positive regulator for resistance against the root-knot nematode Meloidogyne javanica by activating lipids and hormone-mediated defense-signaling pathways.
Article in Plant signaling & behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Grasping Molecular Biology Mechanisms to Optimize Plant Resistance and Advance Microbiome Role Against Phytonematodes.International journal of molecular sciences · 2026Review
- Multi-Omics Reveals Protected Cultivation Improves Chinese Plum (Plants (Basel, Switzerland) · 2026Article
- Cellular plasticity and transcriptional reprogramming in plant-nematode interactions: insights into feeding site formation and plant defense.Crop health · 2025Review
- Combating Root-Knot Nematodes (Plants (Basel, Switzerland) · 2025Review
- Biochemical Defence of Plants against Parasitic Nematodes.Plants (Basel, Switzerland) · 2024Review
- Study on the Function ofInternational journal of molecular sciences · 2024Article
- Tomato SlWRKY3 Negatively RegulatesPlants (Basel, Switzerland) · 2024Article
- Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction.Frontiers in plant science · 2024Review
- SlWRKY16 and SlWRKY31 of tomato, negative regulators of plant defense, involved in susceptibility activation following root-knot nematode Meloidogyne javanica infection.Scientific reports · 2023Article
- Glutathione Transferases Are Involved in the Genotype-Specific Salt-Stress Response of Tomato Plants.Antioxidants (Basel, Switzerland) · 2023Article
- Identification of the Regulatory Role ofPlants (Basel, Switzerland) · 2023Article
- SlWRKY30 and SlWRKY81 synergistically modulate tomato immunity toHorticulture research · 2023Article
- Genomic and metabolic profiling of two tomato contrasting cultivars for tolerance to Tuta absoluta.Planta · 2023Article
- Dynamic interplay ofFrontiers in plant science · 2023Article
- Comprehensive analysis of the WRKY gene family inFrontiers in plant science · 2023Article
- Regulation of the regulators: Transcription factors controlling biosynthesis of plant secondary metabolites during biotic stresses and their regulation by miRNAs.Frontiers in plant science · 2023Review
- Integrated Omic Approaches Reveal Molecular Mechanisms of Tolerance during Soybean andPlants (Basel, Switzerland) · 2022Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2022Article
- Pattern-triggered immunity against root-knot nematode infection: A minireview.Physiologia plantarum · 2022Article
- SlWRKY45 interacts with jasmonate-ZIM domain proteins to negatively regulate defense against the root-knot nematodeHorticulture research · 2022Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diseases caused by plant-parasitic nematodes in vegetables, among them Meloidogyne spp. root-knot nematodes (RKNs), lead to extensive yield decline. A molecular understanding of the mechanisms underlying plants' innate resistance may enable developing safe alternatives to harmful chemical nematicides in controlling RKNs. A tight relationship has been revealed between the WRKY transcription factors and RKN parasitism on tomato roots. We investigated the function role of tomato SlWRK3 and SlWRKY35 in regulating nematode disease development. Using promoter-GUS reporter gene fusions, we show that both SlWRKY3 and SlWRKY35 are induced within 5 days of infection and through feeding-site development and gall maturation, with a much stronger response of the former vs. the latter to nematode infection. Histological analysis of nematode-feeding sites indicated a high expression of SlWRKY3 in developing and mature feeding cells and associated vasculature cells, whereas SlWRKY35 expression was only observed in mature feeding sites. Both SlWRKY3 and SlWRKY35 promoters were induced by the defense phytohormones salicylic acid and indole-3-butyric acid, with no response to either jasmonic acid or methyl jasmonate. SlWRKY3 overexpression resulted in lower infection of the RKN Meloidogyne javanica, whereas knocking down SlWRKY3 resulted in increased infection. Phytohormone and oxylipin profiles determined by LC-MS/MS showed that the enhanced resistance in the former is coupled with an increased accumulation of defense molecules from the shikimate and oxylipin pathways. Our results pinpoint SlWRKY3 as a positive regulator of induced resistance in response to nematode invasion and infection, mostly during the early stages of nematode infection.
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