Evidence map›Paper›PMID 31010302›Full record

ArticleCell transplantation

Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPARγ/FLAP/LTB

Zhaosi Zhang, Guosheng Zhao, Liu Liu, Junchi He, Rami Darwazeh, Han Liu, Hong Chen, Chao Zhou, Zongduo Guo, Xiaochuan Sun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Pathophysiology, Management, and Therapeutics in Subarachnoid Hemorrhage and Delayed Cerebral Ischemia: An Overview.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zhaosi ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Guosheng ZhaoDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Liu LiuDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Junchi HeDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Rami DarwazehDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Han LiuDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hong ChenDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chao ZhouDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zongduo GuoDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaochuan SunDepartment of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
First Affiliated Hospital of Chongqing Medical University · CNChongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular smooth muscle cells (VSMCs) play an important role after a subarachnoid hemorrhage (SAH). The changes in VSMCs following bexarotene treatment after SAH are unknown. In the present study, neurological impairment, decreased cerebral cortical blood flow and transformation of cerebral VSMCs from a contractile to a synthetic phenotype were observed after SAH. Bexarotene reduced neurological impairment, improved cerebral cortical blood flow, inhibited VSMC phenotypic transformation and suppressed the expression of 5-lipoxygenase-activating protein (FLAP) and leukotriene B4 (LTB

Indexed as

5-Lipoxygenase-Activating ProteinsAnimalsBexaroteneCerebral CortexLeukotriene B4MaleMuscle, Smooth, VascularMyocytes, Smooth MusclePPAR gammaRatsRats, Sprague-DawleySubarachnoid Hemorrhage5-Lipoxygenase-Activating ProteinsAlox5ap protein, ratBexaroteneLeukotriene B4PPAR gammaBexaroteneFLAPPPARγsubarachnoid hemorrhagevascular smooth muscle cells

Identifiers

PMID31010302
PMCPMC6767892
OpenAlexW2941688420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.