Evidence map›Paper›PMID 31010169›Full record

ArticleNutrients2019

The Type 2 Diabetes Susceptibility PROX1 Gene Variants Are Associated with Postprandial Plasma Metabolites Profile in Non-Diabetic Men.

Edyta Adamska-Patruno, Joanna Godzien, Michal Ciborowski, Paulina Samczuk, Witold Bauer, Katarzyna Siewko, Maria Gorska, Coral Barbas, Adam Kretowski

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03792685 (Analysis of Genetic Aspects of Metabolic Response on Diet With Different Content of Carbohydrate and Fat. Searching for Genetic Markers for Individualized Therapy in Patients With Obesity and Type 2 Diabetes), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03792685 nacompletednot on this map

Analysis of Genetic Aspects of Metabolic Response on Diet With Different Content of Carbohydrate and Fat. Searching for Genetic Markers for Individualized Therapy in Patients With Obesity and Type 2 Diabetes

TypeinterventionalSponsorMedical University of BialystokRan2009 to 2021Enrolled150ConditionsOverweight and Obesity, Diabetes Mellitus, Type 2, Metabolic Syndrome, Genetic PredispositionArmsNormo-carbohydrate meal intake, High-carbohydrate meal intake, High-fat meal intake, High-protein meal intake
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. KAmerican journal of physiology. Cell physiology · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Two rare PROX1 variants in patients with lymphedema.Molecular genetics & genomic medicine · 2020
    Article
  11. Cell Fate Determination of Lymphatic Endothelial Cells.International journal of molecular sciences · 2020
    Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Edyta Adamska-PatrunoClinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland. edyta.adamska@umb.edu.pl.ORCID 0000-0002-8805-0744
Joanna GodzienClinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland. joannagodzien@gmail.com.
Michal CiborowskiClinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland. michal.ciborowski@umb.edu.pl.ORCID 0000-0003-3729-0518
Paulina SamczukClinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland. paulina.samczuk@gmail.com.ORCID 0000-0001-7815-1149
Witold BauerClinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland. witold.bauer@umb.edu.pl.ORCID 0000-0003-0776-6714
Katarzyna SiewkoDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland. katarzynasiewko@o2.pl.
Maria GorskaDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland. mgorska25@wp.pl.
Coral BarbasCenter for Metabolomics and Bioanalysis (CEMBIO), Universidad CEU San Pablo, 28003 Madrid, Spain. cbarbas@ceu.es.
Adam KretowskiClinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland. adamkretowski@wp.pl.
Medical University of Białystok · PLUniversidad San Pablo CEU · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prospero homeobox 1 (PROX1) gene may show pleiotropic effects on metabolism. We evaluated postprandial metabolic alterations dependently on the rs340874 genotypes, and 28 non-diabetic men were divided into two groups: high-risk (HR)-genotype (CC-genotype carriers,

Indexed as

Polymorphism, Single NucleotideAcetylcarnitineAdultAllelesBile Acids and SaltsDiabetes Mellitus, Type 2DietDietary CarbohydratesGene-Environment InteractionGenotypeHomeodomain ProteinsHumansInflammationLinoleic AcidsLipid MetabolismMaleAcetylcarnitineBile Acids and SaltsDietary CarbohydratesHomeodomain ProteinslinoleamideLinoleic AcidsOrnithineProspero-Related Homeobox 1 ProteinSphingosineTumor Suppressor Proteinshigh-carbohydrate mealnormo-carbohydrate mealnutrigeneticsnutrimetabolomicspostprandial metabolic fingerprintingPROX1 genetype 2 diabetes mellitus riskultra-high performance liquid chromatography

Identifiers

PMID31010169
PMCPMC6520869
OpenAlexW2939292613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.