Evidence map›Paper›PMID 31010150›Full record

ReviewMarine drugs2019

Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery.

Alexander A Braddock, Emmanuel A Theodorakis

Abstract readReview
In one paragraph

Review in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. β-Lactams from the Ocean.Marine drugs · 2023
    Review
  7. Review
  8. ExploringMarine drugs · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexander A BraddockDepartment of Chemistry & Biochemistry, University of California San Diego, La Jolla, CA 92093-0358, USA. aabraddo@ucsd.edu.ORCID 0000-0001-6808-4632
Emmanuel A TheodorakisDepartment of Chemistry & Biochemistry, University of California San Diego, La Jolla, CA 92093-0358, USA. etheodorakis@ucsd.edu.ORCID 0000-0001-9845-6919

Funding

California Breast Cancer Research Program IDEA Award No: 22IB-0024
6 · The paper itself

Abstract

Spirotetronates are actinomyces-derived polyketides that possess complex structures and exhibit potent and unexplored bioactivities. Due to their anticancer and antimicrobial properties, they have potential as drug hits and deserve further study. In particular, abyssomicin C and tetrocarcin A have shown significant promise against antibiotic-resistant

Indexed as

AminoglycosidesAnti-Bacterial AgentsAnti-Infective AgentsBridged Bicyclo Compounds, HeterocyclicDrug DiscoveryHumansMethicillin-Resistant Staphylococcus aureusPolyketidesSpiro Compoundsabyssomicin CAminoglycosidesAnti-Bacterial AgentsAnti-Infective AgentsBridged Bicyclo Compounds, HeterocyclicPolyketidesSpiro Compoundstetrocarcin AantibioticanticancerBcl-2 inhibitorbiosynthesisDiels-AlderDiels-Alderasedrug resistancenatural productpABA inhibitorspirotetronatetotal synthesisUPR apoptosis

Identifiers

PMID31010150
PMCPMC6521127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.