Evidence map›Paper›PMID 31009808›Full record

ArticleMicrobes and infection

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection.

Diane Ly, Deborah Donahue, Mark J Walker, Victoria A Ploplis, Jason D McArthur, Marie Ranson, Francis J Castellino, Martina L Sanderson-Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbes and infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Diane LyIllawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia.
Deborah DonahueW. M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.
Mark J WalkerSchool of Chemistry and Molecular Bioscience, Australian Infectious Diseases Research Centre, University of Queensland, St. Lucia, Queensland, Australia.
Victoria A PloplisW. M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.
Jason D McArthurIllawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia.
Marie RansonIllawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia.
Francis J CastellinoW. M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, United States.
Martina L Sanderson-SmithIllawarra Health and Medical Research Institute and School of Chemistry and Molecular Bioscience, Molecular Horizons, University of Wollongong, Wollongong, New South Wales, Australia. Electronic address: martina@uow.edu.au.
Illawarra Health and Medical Research Institute · AUUniversity of Notre Dame · USUniversity of Queensland · AUUniversity of Wollongong · AU

Funding

STRUCTURE-FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR01HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 1985 to 2021
$7.9M
Plasminogen and Plasmin: Structure and FunctionR56HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J, LEE, SHAUN · 2022 to 2022
$743k
STRUCTURE/FUNCTION STUDIES ON PLASMINOGEN AND PLASMINR37HL013423 · NHLBI · UNIVERSITY OF NOTRE DAME · PI CASTELLINO, FRANCIS J · 1990 to 1999
–
NHLBI NIH HHS R01 HL013423NHLBI NIH HHS R37 HL013423NHLBI NIH HHS R56 HL013423
6 · The paper itself

Abstract

Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA

Indexed as

AnimalsBacterial LoadDisease Models, AnimalMiceMice, Mutant StrainsMice, TransgenicMicrobial ViabilityMutationStreptococcal InfectionsStreptococcus pyogenesTissue Plasminogen ActivatorVirulencePLAT protein, humanTissue Plasminogen ActivatorAnimal infection modelPlasminogenStreptococcus pyogenesStreptokinaseTissue-type plasminogen activator (tPA)Urokinase plasminogen activator (uPA)

Identifiers

PMID31009808
PMCPMC7707001
OpenAlexW2935946695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.