Evidence map›Paper›PMID 31009580›Full record

ReviewJournal of dental research2019

The Role of Exopolysaccharides in Oral Biofilms.

C Cugini, M Shanmugam, N Landge, N Ramasubbu

Abstract readReview
In one paragraph

Review in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Overexpression of ASFrontiers in cellular and infection microbiology · 2026
    Article
  8. Buprenorphine enhancesJournal of oral microbiology · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Asiatic Acid Disrupts the Biofilm Virulence ofInternational journal of molecular sciences · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

C Cugini1 Department of Oral Biology, Center for Oral Biology Research, Rutgers School of Dental Medicine, Newark, NJ, USA.
M Shanmugam1 Department of Oral Biology, Center for Oral Biology Research, Rutgers School of Dental Medicine, Newark, NJ, USA.
N Landge1 Department of Oral Biology, Center for Oral Biology Research, Rutgers School of Dental Medicine, Newark, NJ, USA.
N Ramasubbu1 Department of Oral Biology, Center for Oral Biology Research, Rutgers School of Dental Medicine, Newark, NJ, USA.ORCID 0000-0003-3198-8296

Funding

PGA exopolysaccharide in biofilm formation and pathogenicity of Aggregatibacter aR01DE022544 · NIDCR · UNIV OF MED/DENT OF NJ-NJ DENTAL SCHOOL · PI RAMASUBBU, NARAYANAN, SCHREINER, HELEN CAROL · 2013 to 2016
$1.4M
Role of Dispersin B in the colonization and virulence of Aggregatibacter actinomycetemcomitansR21DE027125 · NIDCR · RBHS-SCHOOL OF DENTAL MEDICINE · PI CUGINI, CARLA, RAMASUBBU, NARAYANAN · 2018 to 2019
$437k
NIDCR NIH HHS R01 DE022544NIDCR NIH HHS R21 DE027125
6 · The paper itself

Abstract

The oral cavity contains a rich consortium of exopolysaccharide-producing microbes. These extracellular polysaccharides comprise a major component of the oral biofilm. Together with extracellular proteins, DNA, and lipids, they form the biofilm matrix, which contributes to bacterial colonization, biofilm formation and maintenance, and pathogenesis. While a number of oral microbes have been studied in detail with regard to biofilm formation and pathogenesis, the exopolysaccharides have been well characterized for only select organisms, namely

Indexed as

BiofilmsPolysaccharides, BacterialAggregatibacter actinomycetemcomitansHumansMouthStreptococcus mutansPolysaccharides, Bacterialbacteriacariesextracellular matrixmicrobiologyperiodontal diseaseplaque/plaque biofilms

Identifiers

PMID31009580
PMCPMC6589894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.