ArticlePLoS computational biology2019
Weak electric fields promote resonance in neuronal spiking activity: Analytical results from two-compartment cell and network models.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Effects of Extracellular Resistance on Neuronal Sensitivity Under Weak Alternating Electric Field Stimulation: A Computational Study.Biomimetics (Basel, Switzerland) · 2026Article
- Demonstration of Alpha-Band Entrainment via Low-Field Magnetic Stimulation: A Simulation-Driven Proof of Concept.Bioengineering (Basel, Switzerland) · 2026Article
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- Regular afferent activity and structural homogeneity gate ephaptic synchronization in the dorsal column.Frontiers in human neuroscience · 2026Article
- Multi-scale model of neural entrainment by transcranial alternating current stimulation in realistic cortical anatomy.Journal of computational neuroscience · 2025Article
- Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem.PLoS computational biology · 2025Article
- Effects of transcranial alternating current stimulation on Spike train correlation in two-compartment model neurons.Biological cybernetics · 2025Article
- Morphological variability may limit single-cell specificity to electric field stimulation.Frontiers in synaptic neuroscience · 2025Article
- Parvalbumin expression does not account for discrete electrophysiological profiles of glutamatergic ventral pallidal subpopulations.Addiction neuroscience · 2024Article
- Frequency-domain analysis of membrane polarization in two-compartment model neurons with weak alternating electric fields.Cognitive neurodynamics · 2024Article
- Intensity- and frequency-specific effects of transcranial alternating current stimulation are explained by network dynamics.bioRxiv : the preprint server for biology · 2023Article
- Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation.Trends in cognitive sciences · 2023Review
- Effects of transcranial alternating current stimulation on spiking activity in computational models of single neocortical neurons.NeuroImage · 2022Article
- Low-rate firing limit for neurons with axon, soma and dendrites driven by spatially distributed stochastic synapses.PLoS computational biology · 2020Article
- Second waves, social distancing, and the spread of COVID-19 across the USA.Wellcome open research · 2020Article
- Inferring and validating mechanistic models of neural microcircuits based on spike-train data.Nature communications · 2019Article
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2 authors.
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Abstract
Transcranial brain stimulation and evidence of ephaptic coupling have sparked strong interests in understanding the effects of weak electric fields on the dynamics of neuronal populations. While their influence on the subthreshold membrane voltage can be biophysically well explained using spatially extended neuron models, mechanistic analyses of neuronal spiking and network activity have remained a methodological challenge. More generally, this challenge applies to phenomena for which single-compartment (point) neuron models are oversimplified. Here we employ a pyramidal neuron model that comprises two compartments, allowing to distinguish basal-somatic from apical dendritic inputs and accounting for an extracellular field in a biophysically minimalistic way. Using an analytical approach we fit its parameters to reproduce the response properties of a canonical, spatial model neuron and dissect the stochastic spiking dynamics of single cells and large networks. We show that oscillatory weak fields effectively mimic anti-correlated inputs at the soma and dendrite and strongly modulate neuronal spiking activity in a rather narrow frequency band. This effect carries over to coupled populations of pyramidal cells and inhibitory interneurons, boosting network-induced resonance in the beta and gamma frequency bands. Our work contributes a useful theoretical framework for mechanistic analyses of population dynamics going beyond point neuron models, and provides insights on modulation effects of extracellular fields due to the morphology of pyramidal cells.
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