Evidence map›Paper›PMID 31009406›Full record

ArticleClinical and translational gastroenterology2019

Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts.

Elsie T Mensah, Thomas Smyrk, Lizhi Zhang, Benjamin Bick, Christina M Wood-Wentz, Navtej Buttar, Suresh T Chari, Ferga C Gleeson, Michael Kendrick, Michael Levy and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Elsie T MensahDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Thomas SmyrkDepartment of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Lizhi ZhangDepartment of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Benjamin BickDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Christina M Wood-WentzDepartment of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Navtej ButtarDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Suresh T ChariDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Ferga C GleesonDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Michael KendrickDepartment of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Michael LevyDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Randall PearsonDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Bret T PetersenDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Santhi VegeDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Felicity EndersDepartment of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Paul LimburgDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Mark TopazianDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · USWinnMed · USMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesExpression of prostaglandin biosynthetic pathway enzymes in mucinous pancreatic cysts is unknown. Cyclooxygenase-2 (COX-2) inhibition is a potential cancer chemoprevention strategy for these lesions. We evaluated the expression of COX-2, cytosolic phospholipase A2 (cPLA2), and protein kinase B (AKT) in the epithelium of pancreatic cysts and correlated enzyme expression with aspirin (ASA) use and cyst fluid prostaglandin E2 (PGE2) concentration.

methodsPathology of 80 resected pancreatic cysts was reviewed. Expression of COX-2, cPLA2, and AKT was quantified by tissue immunohistochemistry immunoreactivity scores (IRSs). IRS values were compared between cyst types and (in 30 cases) with matched cyst fluid PGE2 concentrations.

resultsThe mean IRS was higher in the epithelium of mucinous vs nonmucinous cysts for COX-2 (6.1 ± 4.7 vs 3.2 ± 2.8, P = 0.01) and cPLA2 (6.9 ± 3.0 vs 2.9 ± 2.9, P < 0.001). Cyst epithelial COX-2 expression was higher in mucinous cysts with low-grade dysplasia vs those with high-grade dysplasia or invasive carcinoma (IRS 8.0 ± 3.9 vs 1.5 ± 2.9, P < 0.001), whereas the opposite was found for cPLA2 (6.2 ± 3.0 vs 8.6 ± 2.3, P = 0.005). Cyst fluid PGE2 concentrations did not correlate with either the IRS or a history of low- to moderate-dose ASA use.

conclusionsCOX-2 and cPLA2 are overexpressed in the epithelium of mucinous pancreatic cysts. COX-2 and/or cPLA2 inhibition might prevent the emergence or progression of mucinous pancreatic cysts, but higher doses of ASA or nonsteroidal anti-inflammatory drugs may be necessary to substantially inhibit cyst epithelial COX-2 activity.

Indexed as

AdultAgedAged, 80 and overAspirinCarcinoma, Pancreatic DuctalCyclooxygenase 2Cyclooxygenase InhibitorsCyst FluidDinoprostoneEpitheliumFemaleHumansMaleMiddle AgedPancreasPancreatic CystAspirinCyclooxygenase 2Cyclooxygenase InhibitorsDinoprostonePhospholipases A2, CytosolicProto-Oncogene Proteins c-aktPTGS2 protein, human

Identifiers

PMID31009406
PMCPMC6602781
OpenAlexW2941280767

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.