Evidence map›Paper›PMID 31009264›Full record

ArticleEnvironmental health perspectives2019

Influence of the Urban Exposome on Birth Weight.

Mark J Nieuwenhuijsen, Lydiane Agier, Xavier Basagaña, Jose Urquiza, Ibon Tamayo-Uria, Lise Giorgis-Allemand, Oliver Robinson, Valérie Siroux, Léa Maitre, Montserrat de Castro and 17 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 118 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A Systematic Review and Meta-Analysis of Associations between Green and Blue Spaces and Birth Outcomes.International journal of environmental research and public health · 2020
    Pooled it
  4. Road Traffic Noise Exposure and Depression/Anxiety: An Updated Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2019
    Pooled it
  5. Road Traffic Noise Exposure and Birth Outcomes: An Updated Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2019
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 10 institutions in 8 countries.

Mark J Nieuwenhuijsen1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
Lydiane Agier4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.
Xavier Basagaña1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
Jose Urquiza1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
Ibon Tamayo-Uria5 Department of Statistics, Faculty of Arts and Sciences, Harvard University , Cambridge, Massachusetts, USA.
Lise Giorgis-Allemand4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.
Oliver Robinson6 MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , London, UK.
Valérie Siroux4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.
Léa Maitre1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
Montserrat de Castro1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
Antonia Valentin1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
David Donaire1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
Payam Dadvand1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
Gunn Marit Aasvang7 Norwegian Institute of Public Health (NIPH) , Oslo, Norway.
Norun Hjertager Krog7 Norwegian Institute of Public Health (NIPH) , Oslo, Norway.
Per E Schwarze7 Norwegian Institute of Public Health (NIPH) , Oslo, Norway.
Leda Chatzi6 MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , London, UK.
Regina Grazuleviciene11 Vytauto Didžiojo Universitetas , Kaunas, Lithuania.
Sandra Andrusaityte11 Vytauto Didžiojo Universitetas , Kaunas, Lithuania.
Audrius Dedele11 Vytauto Didžiojo Universitetas , Kaunas, Lithuania.
Rosie McEachan12 Bradford Institute for Health Research Bradford , Bradford, UK.
John Wright12 Bradford Institute for Health Research Bradford , Bradford, UK.
Jane West12 Bradford Institute for Health Research Bradford , Bradford, UK.
Jesús Ibarluzea3 CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain.
Ferran Ballester2 Universitat Pompeu Fabra (UPF) , Barcelona, Spain.
Martine Vrijheid1 ISGlobal (Institute for Global Health) , Barcelona, Spain.
Rémy Slama4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.
Universitat Pompeu Fabra · ESCentre National de la Recherche Scientifique · FRNorwegian Institute of Public Health · NOUniversity of Bradford · GBVytautas Magnus University · LTHarvard University · USImperial College London · GBUniversitat Jaume I · ESUniversity of Southern California · USUniversity of the Basque Country · ES

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Medical Research Council G0601712Medical Research Council MR/K006665/1Medical Research Council MR/K021656/1NIEHS NIH HHS N01 ES075558NIEHS NIH HHS P30 ES007048NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

backgroundThe exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.

objectiveWe evaluated the association of the urban exposome with birth weight.

methodsWe estimated exposure to the urban exposome, including the built environment, air pollution, road traffic noise, meteorology, natural space, and road traffic (corresponding to 24 environmental indicators and 60 exposures) for nearly 32,000 pregnant women from six European birth cohorts. To evaluate associations with either continuous birth weight or term low birth weight (TLBW) risk, we primarily relied on the Deletion-Substitution-Addition (DSA) algorithm, which is an extension of the stepwise variable selection method. Second, we used an exposure-by-exposure exposome-wide association studies (ExWAS) method accounting for multiple hypotheses testing to report associations not adjusted for coexposures.

resultsThe most consistent statistically significant associations were observed between increasing green space exposure estimated as Normalized Difference Vegetation Index (NDVI) and increased birth weight and decreased TLBW risk. Furthermore, we observed statistically significant associations among presence of public bus line, land use Shannon's Evenness Index, and traffic density and birth weight in our DSA analysis.

conclusionThis investigation is the first large urban exposome study of birth weight that tests many environmental urban exposures. It confirmed previously reported associations for NDVI and generated new hypotheses for a number of built-environment exposures. https://doi.org/10.1289/EHP3971.

Indexed as

Birth WeightExposomeCitiesCohort StudiesEnvironmental ExposureEuropeFemaleHumansInfant, NewbornPregnancy

Identifiers

PMID31009264
PMCPMC6785228
OpenAlexW2941416238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.