Evidence map›Paper›PMID 31009234›Full record

ReviewJournal of child and adolescent psychopharmacology2019

Pharmacological Treatment of Youth Substance Use Disorders.

Lindsay M Squeglia, Matthew C Fadus, Erin A McClure, Rachel L Tomko, Kevin M Gray

Open access · greenAbstract readReview
In one paragraph

Review in Journal of child and adolescent psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. A Randomized Controlled Trial of N-acetylcysteine for Adolescent and Young Adult Alcohol Use Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Trial
  5. The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: A randomized controlled clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  6. Trial
  7. Journal of psychoactive drugs · 2026
    Article
  8. Article
  9. Dynamic associations between cannabis use and sleep in adolescents and young adults during a cannabis intervention trial.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lindsay M SquegliaDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.
Matthew C FadusDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.
Erin A McClureDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.
Rachel L TomkoDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.
Kevin M GrayDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.
Medical University of South Carolina · US

Funding

Interdisciplinary Women's Health Research at MUSCK12HD055885 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCGINTY, JACQUELINE F. · 2007 to 2021
$7.2M
Drug Abuse Research Training (DART) ProgramR25DA020537 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KATHLEEN T. BRADY, Sudie E Back · 2006 to 2026
$6.3M
A Proof-of-Concept Trial of N-Acetylcysteine for Adolescent Alcohol Use DisorderR01AA027399 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRAY, KEVIN M, SQUEGLIA, LINDSAY · 2018 to 2022
$3.5M
N-Acetylcysteine and Contingency Management for Youth Cannabis Use DisorderR01DA042114 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRAY, KEVIN M · 2017 to 2021
$3.1M
Neuroscience-informed Treatment Development for Adolescent Alcohol Use DisordersK23AA025399 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SQUEGLIA, LINDSAY · 2016 to 2020
$1.0M
Technological Innovations for the Remote Monitoring of Smoking in AdolescentsK01DA036739 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCCLURE, ERIN A · 2014 to 2018
$771k
NIAAA NIH HHS K23 AA025399NIAAA NIH HHS R01 AA027399NICHD NIH HHS K12 HD055885NIDA NIH HHS K01 DA036739NIDA NIH HHS R01 DA042114NIDA NIH HHS R25 DA020537
6 · The paper itself

Abstract

While the majority of youth who experiment with alcohol and drugs do not develop problematic levels of use, 5% of adolescents and 15% of young adults meet criteria for a substance use disorder (SUD). Pharmacotherapy, in combination with behavioral interventions, has the potential to increase the likelihood of successful treatment for youth struggling with SUD; however, the literature in this area is limited. To date, there are no Food and Drug Administration (FDA)-approved medications for adolescent SUD, other than buprenorphine, which has been approved down to 16 years of age for opioid use disorder. Despite alcohol and cannabis being the most commonly used substances during adolescence, only three medications have been tested among this demographic, and only two have warranted further study (i.e., naltrexone for alcohol and

Indexed as

AdolescentAge FactorsAlcoholismBehavior TherapyCombined Modality TherapyHumansMedication AdherenceSmoking CessationSubstance-Related DisordersTobacco Use DisorderYoung Adultadolescentalcoholcannabisopioidpharmacotherapytobacco

Identifiers

PMID31009234
PMCPMC6727439
OpenAlexW2941771041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.