Evidence map›Paper›PMID 31008597›Full record

ArticleThe journal of physical chemistry. B2019

Polyglutamine Solution-State Structural Propensity Is Repeat Length Dependent.

Ryan S Jakubek, Riley J Workman, Stephen E White, Sanford A Asher

Open access · greenAbstract read
In one paragraph

Article in The journal of physical chemistry. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Riley J WorkmanDepartment of Chemistry and Biochemistry, Center for Computational Sciences , Duquesne University , Pittsburgh , Pennsylvania 15282 , United States.
University of Pittsburgh · USDuquesne University · US

Funding

Training in the Molecular Biophysics and Structural BiologyT32GM088119 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HINCK, ANDREW P · 2011 to 2020
$1.6M
CRCNS: Computational and experimental study of dopamine and serotonin transporterR01DA027806 · NIDA · DUQUESNE UNIVERSITY · PI MADURA, JEFFRY D. · 2009 to 2013
$1.5M
NIDA NIH HHS R01 DA027806NIGMS NIH HHS T32 GM088119
6 · The paper itself

Abstract

Expanded polyglutamine (polyQ) tracts in proteins, which are known to induce their aggregation, are associated with numerous neurodegenerative diseases. Longer polyQ tracts correlate with faster protein aggregation kinetics and a decreased age of onset for polyQ disease symptoms. Here, we use UV resonance Raman spectroscopy, circular dichroism spectroscopy, and metadynamics simulations to investigate the solution-state structures of the D

Indexed as

KineticsMolecular Dynamics SimulationPeptidesProtein Conformation, beta-StrandProtein MultimerizationThermodynamicsPeptidespolyglutamine

Identifiers

PMID31008597
PMCPMC7011583
OpenAlexW2941139194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.