ArticleJournal of research on adolescence : the official journal of the Society for Research on Adolescence2020
Polygenic Influences on Pubertal Timing and Tempo and Depressive Symptoms in Boys and Girls.
Article in Journal of research on adolescence : the official journal of the Society for Research on Adolescence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 39 citations in OpenAlex.
- Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study.BMC medicine · 2024Article
- Article
- The influence of the trajectory of obesity indicators on the age of pubertal onset and pubertal tempo in girls: A longitudinal study in Chongqing, China.Frontiers in public health · 2023Article
- Father absence, age at menarche, and genetic confounding: A replication and extension using a polygenic score.Development and psychopathology · 2022Article
- Article
- Sex-Specific Associations Between Trauma Exposure, Pubertal Timing, and Anxiety in Black Children.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This study used polygenic scoring (PGS) to test whether puberty-related genes were correlated with depressive symptoms, and whether there were indirect effects through pubertal maturation. The sample included 8,795 adolescents from the Avon Longitudinal Study of Parents and Children (measures of puberty drawn ages 8-17 years; of depressive symptoms at age 16.5 years). The PGS (derived from a genome-wide meta-analysis of later age at menarche) predicted boys' and girls' later pubertal timing, boys' slower gonadal development, and girls' faster breast development. Earlier perceived breast development timing predicted more depressive symptoms in girls. Findings support shared genetic underpinnings for boys' and girls' puberty, contributing to multiple pubertal phenotypes with differences in how these genetic variants affect boys' and girls' development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.