ArticlePhysiological reports2019
Lactation induces increased IPSC bursting in oxytocinergic neurons.
Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Oxytocin in Women's Health and Disease.Frontiers in endocrinology · 2022Review
- Article
- Perinatal activation of ERJournal of neurophysiology · 2021Article
- Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.Journal of neuroendocrinology · 2020Review
- Lactation induces increased IPSC bursting in oxytocinergic neurons.Physiological reports · 2019Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Hypothalamic magnocellular neurosecretory cells (MNCs) undergo dramatic structural reorganization during lactation in female rats that is thought to contribute to the pulsatile secretion of oxytocin critical for milk ejection. MNCs from male rats generate robust bursts of GABAergic synaptic currents, a subset of which are onset-synchronized between MNC pairs, but the functional role of the IPSC bursts is not known. To determine the physiological relevance of IPSC bursts, we compared MNCs from lactating and non-lactating female rats using whole-cell recordings in brain slices. We recorded a sixfold increase in the incidence of IPSC bursts in oxytocin (OT)-MNCs from lactating rats compared to non-lactating rats, whereas there was no change in IPSC bursts in vasopressin (VP)-MNCs. Synchronized bursts of IPSCs were observed in pairs of MNCs in slices from lactating rats. Our data indicate, therefore, that IPSC bursts are upregulated specifically in OT-MNCs during lactation, and may, therefore, contribute via rebound depolarization to the spike trains in OT neurons that lead to reflex milk ejection.
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