ArticleJournal of veterinary internal medicine2019
Glutathione S-transferase theta genotypes and environmental exposures in the risk of canine transitional cell carcinoma.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Canine Urothelial DNA Mutations Are Not Associated With Total Trihalomethanes Concentrations in Municipal Drinking Water.Veterinary and comparative oncology · 2026Article
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- Advancing Veterinary Oncology: Next-Generation Diagnostics for Early Cancer Detection and Clinical Implementation.Animals : an open access journal from MDPI · 2025Review
- Canine on the Couch: The New Canary in the Coal Mine for Environmental Health Research.Environment & health (Washington, D.C.) · 2024Review
- Urothelial genotoxicity of environmental chemicals detected in the urine of healthy dogs and their owners.Journal of clinical and translational science · 2024Article
- Environmental exposures and lymphoma risk: a nested case-control study using the Golden Retriever Lifetime Study cohort.Canine medicine and genetics · 2022Article
- Risk of bladder cancer and lymphoma in dogs is associated with pollution indices by county of residence.Veterinary and comparative oncology · 2022Article
- Comparative Assessment of Pesticide Exposures in Domestic Dogs and Their Owners Using Silicone Passive Samplers and Biomonitoring.Environmental science & technology · 2022Article
- Comparative Analysis of the Glutathione S-Transferase Gene Family of FourInternational journal of genomics · 2021Article
- Environmental chemical exposures in the urine of dogs and people sharing the same households.Journal of clinical and translational science · 2020Article
- Genetic and environmental risk for lymphoma in boxer dogs.Journal of veterinary internal medicine · 2020Article
- Glutathione S-transferase theta genotypes and environmental exposures in the risk of canine transitional cell carcinoma.Journal of veterinary internal medicine · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionTransitional cell carcinoma (TCC) in humans is associated with environmental exposures and variants in glutathione S-transferase (GST) genes. Scottish Terriers have a high breed risk for TCC, but the relationship between genetic and environmental risk in dogs is not fully understood. HYPOTHESES: Scottish Terriers have a higher frequency of GST-theta variants compared to lower risk breeds. Dogs with TCC of any breed have a higher frequency of GST-theta variants along with higher environmental exposures, compared to controls. ANIMALS: One hundred and five Scottish Terriers and 68 controls from lower risk breeds; 69 dogs of various breeds with TCC, and 72 breed- and sex-matched unaffected geriatric dogs.
methodsIn this prospective case-control study, dogs were genotyped for 3 canine GST-theta variants: GSTT1 I2+28 G>A, a GSTT1 3'UTR haplotype, and GSTT5 Asp129_Gln130del. Owners of dogs with TCC and unaffected geriatric controls completed a household environmental questionnaire.
resultsThe GSTT1 3'UTR haplotype and GSTT5 Asp129_Gln130del variants were significantly underrepresented in Scottish Terriers (minor allele frequency [MAF] = 0.000 for both), compared to dogs from lower risk breeds (MAF = 0.108 and 0.100; P ≤ .0002). Dogs with TCC did not differ from unaffected geriatric controls across the 3 investigated loci. Transitional cell carcinoma was associated with household insecticide use (odds ratio [OR] = 4.28, 95% confidence interval [CI] = 1.44-12.33, P = .02), and was negatively associated with proximity to a farm (OR = 0.49, 95% CI = 0.25-0.99, P = .04). CONCLUSIONS AND CLINICAL IMPORTANCE: Low-activity GST-theta loci are unlikely contributors to TCC risk in dogs. Increased risk is associated with household insecticide use, and possibly with less rural households.
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