Evidence map›Paper›PMID 31008520›Full record

ReviewAnnals of the New York Academy of Sciences2019

Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries.

Camila M Chaparro, Parminder S Suchdev

3 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 485 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
485citing papers in PubMed, 9 pooled it
63.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05682261 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effect of Multiple Micronutrient Supplements in Reducing Anemia Among Women of Reproductive Age Compared to Iron-folic Acid at Kebribeyah District in Somali Regional State, Ethiopia- A Community-based Individual Randomized Control Trial

TypeinterventionalSponsorEthiopian Public Health InstituteRan2023 to 2023Enrolled265ConditionsAnemiaArmsUNIMMAP-MMS, IFA, Placebo
NCT06176664 nacompletednot on this mapstarted 2024, after this paper: background citation

Oxygen Therapy for Children With Moderate Hypoxemia in Malawi: Pilot Randomized Control Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2024 to 2024Enrolled21ConditionsPneumoniaArmsLow flow oxygen, High-flow nasal cannula oxygen
NCT07483645 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness and Acceptability of a Liposomal Iron Supplement With Vitamin C and Fiber (LISEFEX®): Observational, Descriptive, Prospective, Longitudinal, Multicenter Study in Mexican Subjects Diagnosed With Mild to Moderate Iron Deficiency Anemia.

TypeobservationalSponsorCarnot LaboratoriesRan2025 to 2026Enrolled74ConditionsIron Deficiency Anemia
3 · Its place in the literature

Who cites it

485 citing papers in PubMed, 9 syntheses or guidelines pooled it, 1,089 citations in OpenAlex.

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425 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Camila M ChaparroIndependent Consultant, International Nutrition.
Parminder S SuchdevDepartment of Pediatrics, Emory University, Atlanta, Georgia.
Centers for Disease Control and Prevention · USNutrition International · CA

Funding

Department of Nutrition for Health and Development of the World Health Organization (WHO)Evidence and Programme Guidance UnitIntramural CDC HHS CC999999World Health Organization
6 · The paper itself

Abstract

Anemia affects a third of the world's population and contributes to increased morbidity and mortality, decreased work productivity, and impaired neurological development. Understanding anemia's varied and complex etiology is crucial for developing effective interventions that address the context-specific causes of anemia and for monitoring anemia control programs. We outline definitions and classifications of anemia, describe the biological mechanisms through which anemia develops, and review the variety of conditions that contribute to anemia development. We emphasize the risk factors most prevalent in low- and middle-income countries, including nutritional deficiencies, infection/inflammation, and genetic hemoglobin disorders. Recent work has furthered our understanding of anemia's complex etiology, including the proportion of anemia caused by iron deficiency (ID) and the role of inflammation and infection. Accumulating evidence indicates that the proportion of anemia due to ID differs by population group, geographical setting, infectious disease burden, and the prevalence of other anemia causes. Further research is needed to explore the role of additional nutritional deficiencies, the contribution of infectious and chronic disease, as well as the importance of genetic hemoglobin disorders in certain populations.

Indexed as

Developing CountriesAnemiaHumansInflammationNutritional StatusPrevalenceRisk Factorsanemiaanemia of inflammationiron deficiency anemianutritional anemias

Identifiers

PMID31008520
PMCPMC6697587
OpenAlexW2941747284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.