ArticleEClinicalMedicine2019
Rapid and Accurate Diagnosis of the Respiratory Disease Pertussis on a Point-of-Care Biochip.
Article in EClinicalMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 68 citations in OpenAlex.
- Machine learning-based risk prediction model for pertussis in children: a multicenter retrospective study.BMC infectious diseases · 2025Article
- Portable in situ temperature-dependent spectroscopy on a low-cost microfluidic platform integrated with a battery-powered thermofoil heater.View (Beijing, China) · 2023Article
- Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis.Trends in analytical chemistry : TRAC · 2022Article
- Article
- Ultrasensitive detection of acephate based on carbon quantum dot-mediated fluorescence inner filter effects.The Analyst · 2022Article
- A new fuzzy rule based multi-objective optimization method for cross-scale injection molding of protein electrophoresis microfluidic chips.Scientific reports · 2022Article
- Clinical evaluation of a new rapid immunochromatographic test for detection of Bordetella pertussis antigen.Scientific reports · 2022Article
- Molecular Detection of Infectious Laryngotracheitis Virus in Chickens with a Microfluidic Chip.Animals : an open access journal from MDPI · 2021Article
- Recent innovations in cost-effective polymer and paper hybrid microfluidic devices.Lab on a chip · 2021Review
- Multicolorimetric ELISA biosensors on a paper/polymer hybrid analytical device for visual point-of-care detection of infection diseases.Analytical and bioanalytical chemistry · 2021Article
- A visual bio-barcode immunoassay for sensitive detection of triazophos based on biochip silver staining signal amplification.Food chemistry · 2021Article
- The impact of pertussis in infants: insights from a hospital-based enhanced surveillance system, Lazio region, Italy, 2016 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Article
- Aptamer-functionalized metal-organic frameworks (MOFs) for biosensing.Biosensors & bioelectronics · 2021Review
- Advances in point-of-care nucleic acid extraction technologies for rapid diagnosis of human and plant diseases.Biosensors & bioelectronics · 2020Review
- Review
- A new method to amplify colorimetric signals of paper-based nanobiosensors for simple and sensitive pancreatic cancer biomarker detection.The Analyst · 2020Article
- Remotely tunable microfluidic platform driven by nanomaterial-mediated on-demand photothermal pumping.Lab on a chip · 2020Article
- A Low-Cost Nanomaterial-based Electrochemical Immunosensor on Paper for High-Sensitivity Early Detection of Pancreatic Cancer.Sensors and actuators. B, Chemical · 2020Article
- A reusable PMMA/paper hybrid plug-and-play microfluidic device for an ultrasensitive immunoassay with a wide dynamic range.Microsystems & nanoengineering · 2020Article
- Microfluidic chip enables single-cell measurement for multidrug resistance in triple-negative breast cancer cells.Cancer drug resistance (Alhambra, Calif.) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPertussis is a highly contagious respiratory disease caused by the bacterium
methodsWe developed a paper/polymer hybrid microfluidic biochip integrated with loop-mediated isothermal amplification (LAMP) method for the rapid and accurate detection of
findingsThe instrument-free detection results could be successfully read by the naked eye within 45 min with a limit of detection (LOD) of 5 DNA copies per well. Our optimized bacterial lysis protocol allowed the direct testing of clinical samples without any complicated sample processing/preparation (i.e. DNA extraction) or the use of any equipment (e.g. centrifuges). The validation of the microfluidic approach was accomplished by testing 100 clinical samples. High sensitivity (100%) and specificity (96%) with respect to real-time PCR were achieved.
interpretationThis microfluidic biochip shows great potential for point-of-care disease diagnosis in various venues including schools and physician's offices, especially in low-resource settings in developing nations.
fundingNIH/NIAID under award number R21AI107415, NIH RCMI Pilot Grant, the Philadelphia Foundation, the Medical Center of the Americas Foundation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.