ArticleBMC rheumatology2019
The utility of ESR, CRP and platelets in the diagnosis of GCA.
Article in BMC rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Diagnostic Accuracy of Symptoms, Physical Signs, and Laboratory Tests for Giant Cell Arteritis: A Systematic Review and Meta-analysis.JAMA internal medicine · 2020Pooled it
- Purtscher-like retinopathy as a presenting ocular manifestation of biopsy-proven giant cell arteritis: A case report.The Journal of international medical research · 2026Article
- Diagnostic Challenges and Modern Therapeutic Strategies in Giant Cell Arteritis.Diagnostics (Basel, Switzerland) · 2026Review
- NMR Spectroscopy-Based Lipoprotein and Glycoprotein Biomarkers Differentiate Acute and Chronic Inflammation in Diverse Healthy and Disease Population Cohorts.Journal of proteome research · 2025Article
- Ocular Manifestations of Giant Cell Arteritis.Advances in ophthalmology and optometry · 2025Article
- Article
- Population-Based Performance of Inflammatory Markers in Giant Cell Arteritis.American journal of ophthalmology · 2025Article
- Causal genes identification of giant cell arteritis in CD4+ Memory t cells: an integration of multi-omics and expression quantitative trait locus analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Diagnostic Dilemmas in Giant Cell Arteritis: Overcoming Anchoring Bias.Case reports in rheumatology · 2025Article
- Assessment of Emergency Department Intraocular Pressure and Visual Acuity Assessment as a Screening Exam.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Risk Factors and Pharmacological Interventions Impacting Cerebrovascular Ischemic Events in Giant Cell Arteritis: A Narrative Review.Immunity, inflammation and disease · 2025Review
- Predictive biomarkers of response to tocilizumab in giant cell arteritis (GCA): correlations with imaging activity.Immunologic research · 2024Article
- Histopathology reporting of temporal artery biopsy specimens for giant cell arteritis: results of a modified Delphi study.Journal of clinical pathology · 2024Article
- [Laboratory diagnostics for vasculitis beyond antineutrophil cytoplasmatic autoantibodies].Zeitschrift fur Rheumatologie · 2024Review
- Distinguishing laboratory characteristics in giant cell arteritis: a real-world retrospective cohort study.International ophthalmology · 2023Article
- C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.Diseases (Basel, Switzerland) · 2023Review
- Clinical, biological, and ophthalmological characteristics differentiating arteritic from non-arteritic anterior ischaemic optic neuropathy.Eye (London, England) · 2023Article
- Atypical giant cell arteritis presentations diagnosed with FDG-18 whole body PET imaging.BMJ case reports · 2023Article
- Biomarkers in the era of targeted therapy in giant cell arteritis and polymyalgia rheumatica: is it possible to replace acute-phase reactants?Frontiers in immunology · 2023Review
- Clinical Diagnosis of Temporal Arteritis With Seronegative and Negative Biopsy Studies.Cureus · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo compare the utility of ESR, CRP and platelets for the diagnosis of GCA.
methodA clinical diagnosis of GCA was determined by case-note review of 270 individuals (68% female, mean age 72 years) referred to a central pathology service for a temporal artery biopsy between 2011 and 2014. The highest levels of ESR, CRP and platelets (within 2 weeks of diagnosis) were documented. Evaluation of ESR, CRP and platelets for the diagnosis of GCA were compared using Receiver Operating Characteristic Area Under the Curve (ROC-AUC), and sensitivity/specificity at optimum cut-off values.
resultsGCA was clinically diagnosed in 139 (67%) patients, with 81 TAB positive. The AUC estimates for ESR, CRP and platelets were comparable (0.65 vs 0.72 vs 0.72,
conclusionESR, CRP and platelets are moderate, equivalent diagnostic tests for GCA, but may yield disparate results in individual patients. A combination of CRP and platelet tests may provide the best diagnostic utility for GCA.
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Registered trials
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