ArticleEndocrinology, diabetes & metabolism2019
Stopping antibiotics after surgical amputation in diabetic foot and ankle infections-A daily practice cohort.
Article in Endocrinology, diabetes & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04081792 (Optimization of the Surgical and Medical Management of Diabetic Foot Infections), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimization of the Surgical and Medical Management of Diabetic Foot Infections
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- [Practical guideline on the prevention and management of diabetic foot in China (Ⅰ)].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Guideline
- Staged management of infected diabetic foot ulcers: a 300-patient cohort study on prognostic grading, pathogen dynamics, and individualized risk prediction.Frontiers in medicine · 2026Article
- Practical guidelines for the prevention and management of diabetic foot disease in China.Burns & trauma · 2025Article
- Challenges and Solutions in Advanced Management of Diabetic Foot Infections: A Review of Recent Studies.Journal of diabetes research · 2025Review
- Article
- Evaluation and Management of Diabetes-related Foot Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Detection, management, and prevention of diabetes-related foot disease in the Australian context.World journal of diabetes · 2023Review
- Current knowledge of morbidities and direct costs related to diabetic foot disorders: a literature review.Frontiers in endocrinology · 2023Review
- Pseudomonal Diabetic Foot Infections: Vive la Différence?Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
- Association Between Foot Surgery Type and Subsequent Healing in Veterans With Moderate-to-Severe Diabetic Foot Infections.Open forum infectious diseases · 2022Article
- Short and oral antimicrobial therapy for diabetic foot infection: a narrative review of current knowledge.Journal of bone and joint infection · 2022Review
- How good are clinicians in predicting the presence ofEndocrinology, diabetes & metabolism · 2021Observational
- Treating Diabetic Foot Osteomyelitis: A Practical State-of-the-Art Update.Medicina (Kaunas, Lithuania) · 2021Review
- Optimization of the antibiotic management of diabetic foot infections: protocol for two randomized controlled trials.Trials · 2020Article
- Stopping antibiotics after surgical amputation in diabetic foot and ankle infections-A daily practice cohort.Endocrinology, diabetes & metabolism · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe appropriate duration of antibiotic therapy for diabetic foot infections (DFI) after surgical amputations in toto is debated. There are discrepancies worldwide.
methodsUsing a clinical pathway for adult DFI patients (retrospective cohort analysis), we conducted a cluster-controlled Cox regression analysis. Minimum follow-up was 2 months.
resultsWe followed 482 amputated DFI episodes for a median of 2.1 years after the index episode. The DFIs predominately affected the forefoot (n = 433; 90%). We diagnosed osteomyelitis in 239 cases (239/482; 50%). In total, 47 cases (10%) were complicated by bacteremia, 86 (18%) by abscesses and 139 (29%) presented with cellulitis. Surgical amputation involved the toes (n = 155), midfoot (280) and hindfoot (47). Overall, 178 cases (37%) required revascularization. After amputation, the median duration of antibiotic administration was 7 days (interquartile range, 1-16 days). In 109 cases (25%), antibiotics were discontinued immediately after surgery. Overall, clinical failure occurred in 90 DFIs (17%), due to the same pathogens in only 38 cases. In multivariate analysis, neither duration of total postsurgical antibiotic administration (HR 1.0, 95% CI 0.99-1.01) nor immediate postoperative discontinuation altered failure rate (HR 0.9, 0.5-1.5).
conclusionAccording to our clinical pathway, we found no benefit in continuing postsurgical antibiotic administration in routine amputation for DFI. In the absence of residual infection (ie, resection at clear margins), antibiotics should be discontinued.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.