ArticleEuropean stroke journal2017
Increased risk for posterior circulation ischaemia in patients with vertebral artery hypoplasia: A systematic review and meta-analysis.
Article in European stroke journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Vertebral Artery Hypoplasia and Posterior Circulation Vulnerability: A Systematic Review of Epidemiological, Hemodynamic, and Clinical Evidence.Neurology international · 2026Review
- Congenital Anomalies and Variations of the Carotid and Vertebral Arteries: A Case-Based Imaging Review.Tomography (Ann Arbor, Mich.) · 2026Review
- Competitive blood flow from the contralateral vertebral artery signifies a favorable outcome after successful recanalization for acute posterior circulation ischemic stroke.European radiology · 2026Article
- Association of Vertebral Artery Hypoplasia and Vertebrobasilar Cerebrovascular Accident.Medicina (Kaunas, Lithuania) · 2022Article
- Vascular vertigo and dizziness: Diagnostic criteria.Journal of vestibular research : equilibrium & orientation · 2022Article
- A Narrative Review of Contemporary Global Perspectives into Epidemiology, Treatment, and Prognosis of Vertebrobasilar Strokes.Rwanda journal of medicine and health sciences · 2021Review
- Article
- Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study.Frontiers in neurology · 2021Article
- Evaluation of BPPV with vertebral artery values.Neuropsychiatric disease and treatment · 2018Article
- Siltation and tidal effects: a comprehensive, clinical, and didactic approach to reasoning about vertebrobasilar hypoflow conditions.Brazilian journal of otorhinolaryngologyReview
- Hypoplasia of Fourth Part of Vertebral Artery and Its Clinical Significance.Journal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough several study protocols reported that vertebral artery hypoplasia can predispose to posterior circulation ischaemia, the role of vertebral artery hypoplasia in the risk of posterior circulation ischaemia still remains controversial. The aim of the present meta-analysis was to investigate the association of vertebral artery hypoplasia and posterior circulation ischaemia. PATIENTS AND
methodsWe performed a systematic review and random effects meta-analysis of all eligible observational study protocols reporting prevalence rates of vertebral artery hypoplasia in patients with anterior circulation ischaemia and posterior circulation ischaemia.
resultsWe identified eight study protocols including a total of 3875 acute ischemic stroke patients (mean age: 64.2 years, 61.3% males) and reporting a pooled prevalence of vertebral artery hypoplasia 18.6% (95%CI: 10.8-30.0%). In the overall analysis, a significantly higher probability of vertebral artery hypoplasia presence was found in posterior circulation ischaemia patients compared to patients with anterior circulation ischaemia (risk ratio = 2.12, 95%CI: 1.60-2.82, p < 0.001). In the subsequent sensitivity analysis, vertebral artery hypoplasia was again found to be significantly more prevalent in patients with posterior circulation ischaemia compared to anterior circulation ischaemia (risk ratio = 1.81, 95%CI: 1.58-2.06, p < 0.001), with no evidence of heterogeneity (I DISCUSSION: The present report is a meta-analysis of retrospective observational study protocols, with all the inherent limitations of included studies. The heterogeneity on the reported rates of vertebral artery hypoplasia could be attributed to differences in population age, sex, race, imaging protocols and vertebral artery hypoplasia definition between included studies.
conclusionOur meta-analysis provides further evidence for a possible causal relationship between vertebral artery hypoplasia and cryptogenic posterior circulation ischaemia, an association which undoubtedly deserves further investigation in future prospective study protocols.
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