ArticleAdvanced biosystems2018
Enhanced activation and expansion of T cells using mechanically soft elastomer fibers.
Article in Advanced biosystems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Engineered macroporous gelatin scaffolds enhance lymph node fibroblastic reticular cell identity and enable diabetogenic T cell immunomodulation.Biomaterials · 2026Article
- Predicting Mechanosensitive T Cell Expansion from Cell Spreading.Advanced healthcare materials · 2025Article
- Mechanoregulation of lymphocyte cytotoxicity.Nature reviews. Immunology · 2025Review
- Taming Variability in T-Cell Mechanosensing.Cells · 2025Article
- Assaying and classifying T cell function by cell morphology.BioMedInformatics · 2024Article
- Article
- Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment.Journal of materials science. Materials in medicine · 2024Article
- Article
- Preclinical models for development of immune-oncology therapies.Immuno-oncology insights · 2022Article
- Nanoconfinement of microvilli alters gene expression and boosts T cell activation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Green electrospinning for biomaterials and biofabrication.Biofabrication · 2021Article
- Biphasic response of T cell activation to substrate stiffness.Biomaterials · 2021Article
- Engineering approaches for studying immune-tumor cell interactions and immunotherapy.iScience · 2021Review
- Probing T Cell 3D Mechanosensing With Magnetically-Actuated Structures.Frontiers in immunology · 2021Article
- Multi-Factor Clustering Incorporating Cell Motility Predicts T Cell Expansion Potential.Frontiers in cell and developmental biology · 2021Article
- A Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues.ACS applied materials & interfaces · 2020Article
- Modulating T Cell Activation Using Depth Sensing Topographic Cues.Advanced biosystems · 2020Article
- T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ex vivo induction of regulatory T cells from conventional CD4Journal of biomedical materials research. Part A · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Practical deployment of cellular therapies requires effective platforms for producing clinically relevant numbers of high-quality cells. This report introduces a materials-based approach to improving activation and expansion of T cells, which are rapidly emerging as an agent for treating cancer and a range of other diseases. Electrospinning is used to create a mesh of poly(ε-caprolactone) fibers, which is used to present activating ligands to CD3 and CD28, which activate T cells for expansion. Incorporation of poly(dimethyl siloxane) elastomer into the fibers reduces substrate rigidity and enhances expansion of mixed populations of human CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.