Evidence map›Paper›PMID 31008154›Full record

ArticleOptica2018

Reflection phase microscopy using spatio-temporal coherence of light.

Youngwoon Choi, Poorya Hosseini, Jeon Woong Kang, Sungsam Kang, Taeseok Daniel Yang, Min Gyu Hyeon, Beop-Min Kim, Peter T C So, Zahid Yaqoob

Open access · goldAbstract read
In one paragraph

Article in Optica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

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  8. In vivo visualization of butterfly scale cell morphogenesis inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Youngwoon ChoiSchool of Biomedical Engineering, Korea University, Seoul 02841, South Korea.ORCID 0000-0001-8492-8225
Poorya HosseiniLaser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.ORCID 0000-0001-7347-7887
Jeon Woong KangLaser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.ORCID 0000-0003-2012-9023
Sungsam KangLaser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.ORCID 0000-0002-5146-4716
Taeseok Daniel YangSchool of Biomedical Engineering, Korea University, Seoul 02841, South Korea.ORCID 0000-0001-6452-7504
Min Gyu HyeonDepartment of Biomicro System Technology, Korea University, Seoul 02841, South Korea.ORCID 0000-0002-2907-3444
Beop-Min KimSchool of Biomedical Engineering, Korea University, Seoul 02841, South Korea.
Peter T C SoLaser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Zahid YaqoobLaser Biomedical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.ORCID 0000-0003-2487-9497
Korea University · KRMassachusetts Institute of Technology · US

Funding

Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Characterizing mechanisms of sickle cell crisis via dynamic optical assayR01HL121386 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2014 to 2016
$1.7M
Regenerative Healing Using ECM Based ScaffoldsR01NS051320 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YANNAS, IOANNIS V · 2006 to 2009
$1.6M
High Throughput Manufacturing for Three-Dimensional Microfluidic DevicesR44EB012415 · NIBIB · FEMTOFAB, INC. · PI JANG, YUN-HO · 2011 to 2013
$849k
NHLBI NIH HHS R01 HL121386NIBIB NIH HHS P41 EB015871NIBIB NIH HHS R44 EB012415NINDS NIH HHS R01 NS051320
6 · The paper itself

Abstract

Many disease states are associated with cellular biomechanical changes as markers. Label-free phase microscopes are used to quantify thermally driven interface fluctuations, which allow the deduction of important cellular rheological properties. Here, the spatio-temporal coherence of light was used to implement a high-speed reflection phase microscope with superior depth selectivity and higher phase sensitivity. Nanometric scale motion of cytoplasmic structures can be visualized with fine details and three-dimensional resolution. Specifically, the spontaneous fluctuation occurring on the nuclear membrane of a living cell was observed at video rate. By converting the reflection phase into displacement, the sensitivity in quantifying nuclear membrane fluctuation was found to be about one nanometer. A reflection phase microscope can potentially elucidate biomechanical mechanisms of pathological and physiological processes.

Identifiers

PMID31008154
PMCPMC6472928
OpenAlexW2901537774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.