Evidence map›Paper›PMID 31008111›Full record

SynthesisBioMed research international2019

Effectiveness of Platelet-Rich Fibrin as an Adjunctive Material to Bone Graft in Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trails.

Ruimin Liu, Mingdong Yan, Sulin Chen, Wenxiu Huang, Dong Wu, Jiang Chen

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  16. PRF and PRP in Dentistry: An Umbrella Review.Journal of clinical medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruimin LiuSchool of Stomatology, Fujian Medical University, Fuzhou, Fujian 350000, China.
Mingdong YanFujian Biological Materials Engineering and Technology Center of Stomatology, Fuzhou, Fujian 350000, China.ORCID 0000-0002-8330-0345
Sulin ChenFujian Biological Materials Engineering and Technology Center of Stomatology, Fuzhou, Fujian 350000, China.ORCID 0000-0001-8557-3577
Wenxiu HuangDepartment of Oral Implantology, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0003-2939-5846
Dong WuDepartment of Oral Implantology, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, China.
Jiang ChenDepartment of Oral Implantology, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, China.ORCID 0000-0002-2177-7914

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo date, it remains unknown whether the addition of platelet-rich fibrin (PRF) to bone grafts actually improves the effectiveness of maxillary sinus augmentation. This study aimed to perform a meta-analysis to evaluate the efficacy of PRF in sinus lift. MATERIALS AND

methodsPubMed, Embase, and the Cochrane Library were searched. Randomized controlled studies were identified. The risk of bias was evaluated using the Cochrane Collaboration tool.

resultsFive RCTs were included in our meta-analysis. Clinical, radiographic, and histomorphometric outcomes were considered. No implant failure or graft failure was detected in all included studies within the follow-up period. The percentage of contact length between newly formed bone substitute and bone in the PRF group was lower but lacked statistical significance (3.90%, 95% CI, -2.91% to 10.71%). The percentages of new bone formation (-1.59%, 95% CI, -5.36% to 2.18%) and soft-tissue area (-3.73%, 95% CI, -10.11% to 2.66%) were higher in the PRF group but were not significantly different. The percentage of residual bone graft was not significant in either group (4.57%, 95% CI, 0% to 9.14%).

conclusionsWithin the limitations of this review, it was concluded that there were no statistical differences in survival rate, new bone formation, contact between newly formed bone and bone substitute, percentage of residual bone graft (BSV/TV), and soft-tissue area between the non-PRF and PRF groups. Current evidence supporting the necessity of adding PRF to bone graft in sinus augmentation is limited.

Indexed as

Platelet-Rich FibrinSinus Floor AugmentationBone RegenerationBone SubstitutesBone TransplantationDental Implantation, EndosseousHumansMaxillary SinusRandomized Controlled Trials as TopicBone Substitutes

Identifiers

PMID31008111
PMCPMC6441530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.