ArticlePerspectives in clinical research
Are drug-drug interactions a real clinical concern?
Article in Perspectives in clinical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Mapping the Global Research on Drug-Drug Interactions: A Multidecadal Evolution Through AI-Driven Terminology Standardization.Bioengineering (Basel, Switzerland) · 2025Article
- DrIVeNN: Drug Interaction Vectors Neural Network.Journal of computational biology : a journal of computational molecular cell biology · 2025Article
- Real-World Evaluation of the Interaction Between Rifampicin and Warfarin: A Retrospective Observational Study.Advances in pharmacological and pharmaceutical sciences · 2025Article
- Assessment of co-ingestion effects on poisoning patterns, drug-drug interactions, and adverse outcomes in acute toxic exposure.Toxicology reports · 2024Article
- Cognitive task analysis of clinicians' drug-drug interaction management during patient care and implications for alert design.BMJ open · 2023Article
- Efficacy of Short-Term High Dose Pulsed Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-Infections: A Report of Three Cases and Literature Review.Antibiotics (Basel, Switzerland) · 2022Article
- Prevalence and factors associated with polypharmacy and potential drug interactions in adults in Manaus, Amazonas state, Brazil: a cross-sectional population-based study, 2019.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2022Article
- Potential drug interactions in adults living in the Brazilian Amazon: A population-based case-control study, 2019.Exploratory research in clinical and social pharmacy · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAlthough drug-drug interactions (DDIs) cause major adverse drug reactions (ADRs) in patients under polypharmacy, the risk of some specific DDIs may be overrated in literature and different software. This study was conducted to determine the frequency and type of potential and clinically significant DDIs among inpatients admitted in a tertiary care hospital in South India. MATERIALS AND
methodsThis longitudinal study was conducted for 30 days. Preformatted forms were used to collect data on the second day of admission. "Medscape Drug Interaction Checker" was used to evaluate and grade the DDIs. All the potential serious DDIs were intimated to the treating physicians and their responses in the prescriptions were noted. The same patients were followed up to evaluate the occurrence of any clinically significant DDIs.
resultsA total of 763 drugs with 125 discrete types were prescribed in 155 patients with an average of 4.9 drugs per patient. One hundred and eight minor, 169 significant, and 24 serious potential DDIs were identified. Patient's age did not correlate, but number of drugs prescribed strongly correlated (
conclusionThere was a disparity between the potential and clinically relevant DDIs. Hence, clinical prudency is required before changing prescription due to potential DDIs reported by different software.
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