ArticleToxicology reports2019
Formaldehyde produced from d-ribose under neutral and alkaline conditions.
Article in Toxicology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- D-ribose metabolic disorder and diabetes mellitus.Molecular biology reports · 2024Review
- Review
- D-ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review).Experimental and therapeutic medicine · 2021Review
- D-ribose and pathogenesis of Alzheimer's disease.Molecular biology reports · 2020Review
- D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy.Aging · 2019Article
- Protective role of (Bronco-T) against formaldehyde induced antioxidant, oxidative and histopathological changes in lung of male Wistar rats.Toxicology reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formaldehyde is toxic and has been implicated in the pathologies of various diseases, such as cognitive impairment and cancer. Though d-ribose is widely studied and provided as a supplement to food such as flavor and drinks, no laboratories have reported that d-ribose is involved in the formaldehyde production. Here, we show that formaldehyde is produced from d-ribose in lysine or glycine solution and Tris-HCl buffer under neutral and alkaline conditions. Intraperitoneal injection of C57BL/6J mice with d-ribose significantly increased the concentration of brain formaldehyde, compared to the injection with d-glucose or saline. These data suggest that formaldehyde levels should be monitored for the people who take d-ribose as a supplement.
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Registered trials
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