ReviewChemElectroChem2019
Direct Electron Transfer of Enzymes Facilitated by Cytochromes.
Review in ChemElectroChem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self-Sufficient Viral Restriction Factors.Angewandte Chemie (International ed. in English) · 2026Article
- Reducing Flavin and Ubiquinone Headgroups with Silicon Nanowire Photocathodes.Artificial photosynthesis (Washington, D.C.) · 2026Article
- Nanomaterials as electrochemical regulators of bacterial biofilms through the modulation of extracellular electron transport and ion channels.Journal of nanobiotechnology · 2026Review
- Harnessing the power: the role of dissimilatory metal-reducing bacteria in microbial fuel cells.Archives of microbiology · 2025Review
- The application of bacteria-derived dehydrogenases and oxidases in the synthesis of gold nanoparticles.Applied microbiology and biotechnology · 2024Article
- Peroxidase-like Nanoparticles of Noble Metals Stimulate Increasing Sensitivity of FlavocytochromeBiosensors · 2024Article
- Unveiling the role of inorganic nanoparticles in Earth's biochemical evolution through electron transfer dynamics.iScience · 2024Review
- Enzyme Immobilization by Inkjet Printing on Reagentless Biosensors for Electrochemical Phosphate Detection.Biosensors · 2024Article
- Article
- Two disulfide-reducing pathways are required for the maturation of plastid c-type cytochromes in Chlamydomonas reinhardtii.Genetics · 2023Article
- Interdomain Linker of the Bioelecrocatalyst Cellobiose Dehydrogenase Governs the Electron Transfer.ACS catalysis · 2023Article
- An engineered thermally tolerant apo-cytochrome scaffold for metal-less incorporation of heme derivative.PloS one · 2023Article
- Control of carbon monoxide dehydrogenase orientation by site-specific immobilization enables direct electrical contact between enzyme cofactor and solid surface.Communications biology · 2022Article
- Versatile potentiometric metabolite sensing without dioxygen interference.Biosensors & bioelectronics · 2022Article
- Amperometric Biosensors Based on Direct Electron Transfer Enzymes.Molecules (Basel, Switzerland) · 2021Review
- Oxidase-loaded hydrogels for versatile potentiometric metabolite sensing.Biosensors & bioelectronics · 2021Article
- Molecular mechanisms of electron transfer employed by native proteins and biological-inorganic hybrid systems.Computational and structural biotechnology journal · 2021Review
- Cytochrome c-multiwalled carbon nanotube and cobalt metal organic framework/gold nanoparticle immobilized electrochemical biosensor for nitrite detection.RSC advances · 2020Article
- Direct Electron Transfer of Enzymes Facilitated by Cytochromes.ChemElectroChem · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The direct electron transfer (DET) of enzymes has been utilized to develop biosensors and enzymatic biofuel cells on micro- and nanostructured electrodes. Whereas some enzymes exhibit direct electron transfer between their active-site cofactor and an electrode, other oxidoreductases depend on acquired cytochrome domains or cytochrome subunits as built-in redox mediators. The physiological function of these cytochromes is to transfer electrons between the active-site cofactor and a redox partner protein. The exchange of the natural electron acceptor/donor by an electrode has been demonstrated for several cytochrome carrying oxidoreductases. These multi-cofactor enzymes have been applied in third generation biosensors to detect glucose, lactate, and other analytes. This review investigates and classifies oxidoreductases with a cytochrome domain, enzyme complexes with a cytochrome subunit, and covers designed cytochrome fusion enzymes. The structurally and electrochemically best characterized proponents from each enzyme class carrying a cytochrome, that is, flavoenzymes, quinoenzymes, molybdenum-cofactor enzymes, iron-sulfur cluster enzymes, and multi-haem enzymes, are featured, and their biochemical, kinetic, and electrochemical properties are compared. The cytochromes molecular and functional properties as well as their contribution to the interdomain electron transfer (IET, between active-site and cytochrome) and DET (between cytochrome and electrode) with regard to the achieved current density is discussed. Protein design strategies for cytochrome-fused enzymes are reviewed and the limiting factors as well as strategies to overcome them are outlined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.