Evidence map›Paper›PMID 31007963›Full record

ArticleCase reports in transplantation2019

Gastric Mucormycosis in a Renal Transplant Patient Treated with Isavuconazole Monotherapy.

Imran Gani, Atbin Doroodchi, Kristina Falkenstrom, Holly Berry, Won Lee, Laura Mulloy, Muhammad Saeed, Rajan Kapoor

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. OesophagealMedical mycology case reports · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Isavuconazole for Treating Invasive Mould Disease in Solid Organ Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Review
  7. Article
  8. Article
  9. Isavuconazole-Animal Data and Clinical Data.Journal of fungi (Basel, Switzerland) · 2020
    Review
  10. Article
  11. A Rare Case of Drug-ResistantJournal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Imran GaniDepartment of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GA, USA.ORCID 0000-0002-4813-5022
Atbin DoroodchiDivision of Transplant Surgery, Department of Surgery, Augusta University Health, Augusta, GA, USA.
Kristina FalkenstromDivision of Transplant Surgery, Department of Surgery, Augusta University Health, Augusta, GA, USA.
Holly BerryDepartment of Pharmacy, Augusta University Health, Augusta, GA, USA.
Won LeeDepartment of Pathology, Augusta University Health, Augusta, GA, USA.ORCID 0000-0002-0722-669X
Laura MulloyDepartment of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GA, USA.
Muhammad SaeedDivision of Transplant Surgery, Department of Surgery, Augusta University Health, Augusta, GA, USA.ORCID 0000-0002-0627-1253
Rajan KapoorDepartment of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GA, USA.ORCID 0000-0002-8633-7717
Augusta University Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal mucormycosis is a rare infection in solid organ transplant recipients. Our patient, a 79-year-old male, presented with severe dysphagia and odynophagia about 2 weeks after receiving a renal transplant. An upper gastrointestinal (UGI) endoscopy revealed esophagitis and gastric ulceration, the cultures from which grew Rhizopus species. A usual treatment strategy should include Amphotericin B as monotherapy or in combination with Posaconazole or Isavuconazole for such infections. Our patient was treated with Isavuconazole monotherapy, in an effort to minimize renal toxicity from Amphotericin B to the new allograft. Unique to our case was a successful clinical response and resolution of UGI lesions with Isavuconazole monotherapy. Due to the vagueness of presenting symptoms, such infections can be easily missed in an immunocompromised patient which can have tragic outcomes. Prompt diagnosis and modulation of immunosuppression are essential to decrease mortality and morbidity. Isavuconazole is a novel agent and can be used as a monotherapy for such infections, especially in renal transplant recipients.

Identifiers

PMID31007963
PMCPMC6441519
OpenAlexW2921348905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.