ArticleEvolution letters2019
Experimentally reduced insulin/IGF-1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring.
Article in Evolution letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Reduced insulin/IGF-1 signaling extends reproductive span through somatic gonadal collagen-mediated maintenance of oocyte and embryo quality in Caenorhabditis elegans.Cell communication and signaling : CCS · 2026Article
- Why we age.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Integrating evolutionary theory into a framework for the mechanistic evaluation of candidate anti-aging interventions.Frontiers in aging · 2026Article
- Temporal transcriptomic profiling reveals distinct age-associated gene expression signatures in gonads under reduced insulin/IGF-1 signaling in Caenorhabditis elegans.Cell communication and signaling : CCS · 2025Article
- Lifespan-extending downregulation of insulin signalling reduces germline mutation load.bioRxiv : the preprint server for biology · 2025Article
- The cell autonomous and non-autonomous functions of Rab27 in longevity and neuroprotection inAutophagy · 2025Article
- Optimising Age-Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments.Aging cell · 2025Article
- Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans.GeroScience · 2024Article
- Article
- Signatures of selection inEvolutionary applications · 2024Article
- A unified framework for evolutionary genetic and physiological theories of aging.PLoS biology · 2024Article
- Metabolic stress as a driver of life-history plasticity: flight promotes longevity and antioxidant production in monarch butterflies.Proceedings. Biological sciences · 2023Article
- Multigenerational downregulation of insulin/IGF-1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing.Evolution; international journal of organic evolution · 2022Article
- Hallmarks of cancer and hallmarks of aging.Aging · 2022Article
- Review
- Article
- A synthesis of senescence predictions for indeterminate growth, and support from multiple tests in wild lake trout.Proceedings. Biological sciences · 2022Article
- How much energetic trade-offs limit selection? Insights from livestock and related laboratory model species.Evolutionary applications · 2021Article
- Ageing as "early-life inertia": Disentangling life-history trade-offs along a lifetime of an individual.Evolution letters · 2021Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical theory maintains that ageing evolves via energy trade-offs between reproduction and survival leading to accumulation of unrepaired cellular damage with age. In contrast, the emerging new theory postulates that ageing evolves because of deleterious late-life hyper-function of reproduction-promoting genes leading to excessive biosynthesis in late-life. The hyper-function theory uniquely predicts that optimizing nutrient-sensing molecular signaling in adulthood can simultaneously postpone ageing and increase Darwinian fitness. Here, we show that reducing evolutionarily conserved insulin/IGF-1 nutrient-sensing signaling via
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Registered trials
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