ArticleNigerian journal of surgery : official publication of the Nigerian Surgical Research Society
Micronuclei in Exfoliated Cells: A Biomarker of Genotoxicity in Tobacco Users.
Article in Nigerian journal of surgery : official publication of the Nigerian Surgical Research Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 26 citations in OpenAlex.
- Association Between E-Cigarette Use (Vaping) and Oral Health in Adolescents and Young Adults: A Systematic Review.Journal of clinical medicine · 2026Review
- Impact of cigarette smoking on genetic stability, cell division, and cytotoxicity in buccal cells of old and young women.Mutagenesis · 2026Article
- Application of the Buccal Micronucleus Cytome Assay for Genotoxicity Detection in Dogs.Animals : an open access journal from MDPI · 2025Article
- Effect of Age, Hot Beverages and Tobacco Related Products on Buccal Epithelial Cells of Cigarette Smokers and non-Smokers in Ajman, UAE.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- High prevalence of chromosome 17 in breast cancer micronuclei: a means to get rid of tumor suppressors?Human cell · 2024Article
- Evaluation of Cytotoxic and Genotoxic Effects in Buccal Mucosal Cells in Non-Smokers and Users of Traditional Combustible Tobacco Products and Non-Combustible Alternatives.Journal of xenobiotics · 2024Article
- Article
- Micronuclei detection in oral cytologic smear: does it add diagnostic value?Journal of the Egyptian National Cancer Institute · 2023Article
- AFM methods for studying the morphology and micromechanical properties of the membrane of human buccal epithelium cell.Scientific reports · 2023Article
- Re: Evaluation of Micronuclei and Cytomorphometric Changes in Patients with Different Tobacco Related Habits Using Exfoliated Buccal Cells.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- The Effects of E-Cigarette Aerosol on Oral Cavity Cells and Tissues: A Narrative Review.Toxics · 2022Review
- Early Diagnosis of Oral Mucosal Alterations in Smokers and E-Cigarette Users Based on Micronuclei Count: A Cross-Sectional Study among Dental Students.International journal of environmental research and public health · 2021Article
- Evaluation of Micronuclei and Cytomorphometric Changes in Patients with Different Tobacco Related Habits Using Exfoliated Buccal Cells.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Risk of genotoxic damage in schoolchildren exposed to organochloride pesticides.Scientific reports · 2020Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study was to analyze the tobacco-related genotoxic effects in individual with habit of smoking and chewing tobacco. MATERIALS AND
methodsThe present study sample consisted of 120 individuals attending the outpatient department of D. J. College of Dental Sciences and Research, Modinagar, Uttar Pradesh (UP). The sample was divided into four groups as follows: Group I (individuals with habit of smoking tobacco), Group II (individuals with habit of chewing tobacco), Group III (individuals with habit of smoking and chewing tobacco), and Group IV control group (nontobacco-exposed individuals). Patients were asked to rinse their mouth gently with water. The exfoliated cells were obtained by scraping the buccal mucosa of individuals with a wooden spatula. The scraped cells were placed on the precleaned slides. The smears were then stained with RAPID-PAP™ and analyzed under the microscope. Data were analyzed using SPSS statistical software.
resultsIn the present study, an arbitrary unit was obtained using frequency/day multiplied by the duration of years (risk multiplication factor [RMF], a positive and significant correlation were observed between the RMF and the mean percentage of micronucleated cell count in smokers, chewers, and in individuals with both smoking and chewing habit, respectively. A weak positive and nonsignificant correlation were observed between age and mean percentage of micronucleated cells in smokers and smokers + chewers, respectively, while it was weak negative and nonsignificant in chewers. In control group, correlation between age and percentage of micronucleated cells was weak positive and nonsignificant at 5% level of significance.
conclusionThe micronuclei in exfoliated mucosal cells from buccal mucosa can be used as a biomarker of genotoxicity in predicting the effects of carcinogens.
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