Evidence map›Paper›PMID 31007425›Full record

ArticleAnnals of Indian Academy of Neurology

Scrub Typhus-Associated Opsoclonus: Clinical Course and Longitudinal Outcomes in an Indian Cohort.

Ravikar Ralph, A T Prabhakar, Sowmya Sathyendra, Ronald Carey, John Jude, George M Varghese

Open access · diamondAbstract read
In one paragraph

Article in Annals of Indian Academy of Neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Movement Disorders in Scrub Typhus: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. Neurological Manifestations of Scrub Typhus.Current neurology and neuroscience reports · 2022
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Opsoclonus in Scrub Typhus.Annals of Indian Academy of Neurology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ravikar RalphDepartment of Internal Medicine, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
A T PrabhakarDepartment of Neurology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Sowmya SathyendraDepartment of Internal Medicine, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Ronald CareyDepartment of Internal Medicine, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
John JudeDepartment of Clinical Microbiology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
George M VargheseDepartment of Infectious Diseases, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Christian Medical College · INChristian Medical College & Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextOpsoclonus, a rare neurological manifestation in scrub typhus, causes significant distress and disability. There is a paucity of clinical data and outcomes in these patients.

aimThis study aims to describe the clinical and laboratory profile and longitudinal outcomes in a scrub typhus patient cohort with opsoclonus. SETTINGS AND

designThis retrospective study was conducted in a 2700-bed teaching hospital in South India, in scrub typhus patients with opsoclonus over a 5-year period. PATIENTS AND

methodsClinical, laboratory, and radiological data and outcomes at discharge and 6- and 12-weeks postdischarge were documented.

resultsOf 1650 scrub typhus patients, 18 had opsoclonus. 17 had opsoclonus at presentation, while one patient developed opsoclonus on the 5

conclusionsOpsoclonus is a rare neurological manifestation in scrub typhus, usually occurring in association with myoclonus, cerebellar dysfunction, or EPS. It appears to occur during the resolving febrile phase, with neurological deficits completely resolving at 12 weeks.

Indexed as

Opsoclonusopsoclonus–myoclonus syndromescrub typhus

Identifiers

PMID31007425
PMCPMC6472253
OpenAlexW2949041865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.