Evidence map›Paper›PMID 31007268›Full record

ArticleCarbon2013

Disruption of Model Cell Membranes by Carbon Nanotubes.

Charlie Corredor, Wen-Che Hou, Steven A Klein, Babak Y Moghadam, Michael Goryll, Kyle Doudrick, Paul Westerhoff, Jonathan D Posner

Abstract read
In one paragraph

Article in Carbon, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charlie CorredorChemical Engineering, University of Washington, Seattle, WA 98115.
Wen-Che HouEnvironmental Engineering, Arizona State University, Tempe, Arizona 85287-6106.
Steven A KleinMechanical Engineering, Arizona State University, Tempe, Arizona 85287-6106.
Babak Y MoghadamMechanical Engineering, University of Washington, Seattle, WA 98115.
Michael GoryllElectrical Engineering, Arizona State University, Tempe, Arizona 85287-6106.
Kyle DoudrickEnvironmental Engineering, Arizona State University, Tempe, Arizona 85287-6106.
Paul WesterhoffEnvironmental Engineering, Arizona State University, Tempe, Arizona 85287-6106.
Jonathan D PosnerChemical Engineering, University of Washington, Seattle, WA 98115.

Funding

Biomimetic Microsystem for High Throughput Evaluation of Engineered NanomaterialsRC2ES018756 · NIEHS · MICHIGAN STATE UNIVERSITY · PI WORDEN, ROBERT M · 2009 to 2010
$985k
NIEHS NIH HHS RC2 ES018756
6 · The paper itself

Abstract

Carbon nanotubes (CNTs) have one of the highest production volumes among carbonaceous engineered nanoparticles (ENPs) worldwide and are have potential uses in applications including biomedicine, nanocomposites, and energy conversion. However, CNTs possible widespread usage and associated likelihood for biological exposures have driven concerns regarding their nanotoxicity and ecological impact. In this work, we probe the responses of planar suspended lipid bilayer membranes, used as model cell membranes, to functionalized multi-walled carbon nanotubes (MWCNT), CdSe/ZnS quantum dots, and a control organic compound, melittin, using an electrophysiological measurement platform. The electrophysiological measurements show that MWCNTs in a concentration range of 1.6 to 12 ppm disrupt lipid membranes by inducing significant transmembrane current fluxes, which suggest that MWCNTs insert and traverse the lipid bilayer membrane, forming transmembrane carbon nanotubes channels that allow the transport of ions. This paper demonstrates a direct measurement of ion migration across lipid bilayers induced by CNTs. Electrophysiological measurements can provide unique insights into the lipid bilayer-ENPs interactions and have the potential to serve as a preliminary screening tool for nanotoxicity.

Identifiers

PMID31007268
PMCPMC6474754

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.