Evidence map›Paper›PMID 31007090›Full record

ReviewExpert opinion on drug delivery2019

An update on the contribution of hot-melt extrusion technology to novel drug delivery in the twenty-first century: part I.

Venkata Raman Kallakunta, Sandeep Sarabu, Suresh Bandari, Roshan Tiwari, Hemlata Patil, Michael A Repka

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Venkata Raman Kallakuntaa Department of Pharmaceutics and Drug Delivery , The University of Mississippi , Oxford , MS , USA.
Sandeep Sarabua Department of Pharmaceutics and Drug Delivery , The University of Mississippi , Oxford , MS , USA.
Suresh Bandaria Department of Pharmaceutics and Drug Delivery , The University of Mississippi , Oxford , MS , USA.
Roshan Tiwaria Department of Pharmaceutics and Drug Delivery , The University of Mississippi , Oxford , MS , USA.
Hemlata Patila Department of Pharmaceutics and Drug Delivery , The University of Mississippi , Oxford , MS , USA.
Michael A Repkaa Department of Pharmaceutics and Drug Delivery , The University of Mississippi , Oxford , MS , USA.

Funding

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
NIGMS NIH HHS P20 GM104932
6 · The paper itself

Abstract

introductionCurrently, hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products in the market. HME is extensively researched for enhancing the solubility and bioavailability of poor water-soluble drugs, taste masking, and modifying release in drug delivery systems. Additionally, its other novel opportunities or pharmaceutical applications, and capability for continuous manufacturing are being investigated. This efficient, industrially scalable, solvent-free, continuous process can be easily automated and coupled with other novel platforms for continuous manufacturing of pharmaceutical products. AREAS COVERED: This review focuses on updates on solubility enhancement of poorly water-soluble drugs and process analytical tools such as UV/visible spectrophotometry; near-infrared spectroscopy; Raman spectroscopy; and rheometry for continuous manufacturing, with a special emphasis on fused deposition modeling 3D printing. EXPERT OPINION: The strengths, weakness, opportunities, threats (SWOT) and availability of commercial products confirmed wide HME applicability in pharmaceutical research. Increased interest in continuous manufacturing processes makes HME a promising strategy for this application. However, there is a need for extensive research using process analytical tools to establish HME as a dependable continuous manufacturing process.

Indexed as

Drug Delivery SystemsHot Melt Extrusion TechnologyBiological AvailabilityDrug CompoundingDrug IndustryPharmaceutical PreparationsSolubilitySpectrum Analysis, RamanTechnology, PharmaceuticalPharmaceutical Preparations3D printingcontinuous manufacturinghot melt extrusionprocess analytical toolssolubility enhancementSWOT analysis

Identifiers

PMID31007090
PMCPMC6791722

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.