Trial reportClinical trials (London, England)2019
Establishing an electronic health record-supported approach for outreach to and recruitment of persons at high risk of type 2 diabetes in clinical trials: The vitamin D and type 2 diabetes (D2d) study experience.
Trial report in Clinical trials (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Mobile Phone App to Promote Lifestyle Change in People at Risk of Type 2 Diabetes: Feasibility 3-Arm Randomized Controlled Trial.JMIR formative research · 2025Trial
- Use of comprehensive recruitment strategies in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE) multi-center clinical trial.Clinical trials (London, England) · 2023 · on this mapTrial
- Effect of intratrial mean 25(OH)D concentration on diabetes risk, by race and weight: an ancillary analysis in the D2d study.The American journal of clinical nutrition · 2023Trial
- Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.The Journal of clinical endocrinology and metabolism · 2022Trial
- Vitamin D Supplementation and Prevention of Type 2 Diabetes.The New England journal of medicine · 2019Trial
- Strategies for recruiting participants underrepresented in clinical research: A scoping review.Social science & medicine (1982) · 2025Article
- Correlation between hyperlipidemia and serum vitamin D levels in an adult Chinese cohort.Frontiers in nutrition · 2024Article
- Effect of vitamin D on regression to normal glucose regulation and individual glycemic measures: A secondary analysis among participants adherent to the trial protocol in the randomized clinical trial vitamin D and type 2 diabetes (D2d) study.Diabetes research and clinical practice · 2023Article
- Patient Recruitment Into a Multicenter Clinical Cohort Linking Electronic Health Records From 5 Health Systems: Cross-sectional Analysis.Journal of medical Internet research · 2021Article
- An Electronic Data Capture Framework (ConnEDCt) for Global and Public Health Research: Design and Implementation.Journal of medical Internet research · 2020Article
- Vitamin D supplementation for prevention of cancer: The D2d cancer outcomes (D2dCA) study.Contemporary clinical trials · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
aimsTo establish recruitment approaches that leverage electronic health records in multicenter prediabetes/diabetes clinical trials and compare recruitment outcomes between electronic health record-supported and conventional recruitment methods.
methodsObservational analysis of recruitment approaches in the vitamin D and type 2 diabetes (D2d) study, a multicenter trial in participants with prediabetes. Outcomes were adoption of electronic health record-supported recruitment approaches by sites, number of participants screened, recruitment performance (proportion screened who were randomized), and characteristics of participants from electronic health record-supported versus non-electronic health record methods.
resultsIn total, 2423 participants were randomized: 1920 from electronic health record (mean age of 60 years, 41% women, 68% White) and 503 from non-electronic health record sources (mean age of 56.9 years, 58% women, 61% White). Electronic health record-supported recruitment was adopted by 21 of 22 sites. Electronic health record-supported recruitment was associated with more participants screened versus non-electronic health record methods (4969 vs 2166 participants screened), higher performance (38.6% vs 22.7%), and more randomizations (1918 vs 505). Participants recruited via electronic health record were older, included fewer women and minorities, and reported higher use of dietary supplements. Electronic health record-supported recruitment was incorporated in diverse clinical environments, engaging clinicians either at the individual or the healthcare system level.
conclusionEstablishing electronic health record-supported recruitment approaches across a multicenter prediabetes/diabetes trial is feasible and can be adopted by diverse clinical environments.
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