Evidence map›Paper›PMID 31007003›Full record

ArticleJournal of biomedical optics2019

Excitation parameters optimized for coherent anti-Stokes Raman scattering imaging of myelinated tissue.

Craig Brideau, Kelvin W C Poon, Pina Colarusso, Peter K Stys

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Craig BrideauUniversity of Calgary, Hotchkiss Brain Institute, Cumming School of Medicine, Department of Clinical, Canada.
Kelvin W C PoonUniversity of Calgary, Hotchkiss Brain Institute, Cumming School of Medicine, Department of Clinical, Canada.
Pina ColarussoUniversity of Calgary, Department of Physiology and Pharmacology, Calgary, Alberta, Canada.
Peter K StysUniversity of Calgary, Hotchkiss Brain Institute, Cumming School of Medicine, Department of Clinical, Canada.

Funding

CIHR
6 · The paper itself

Abstract

Coherent anti-Stokes Raman scattering (CARS) generates a strong label-free signal in the long wavenumber C─H stretching region. Lipid-rich myelinated tissues, such as brain and spinal cord, would appear to be ideal subjects for imaging with CARS laser-scanning microscopy. However, the highly ordered, biochemically complex, and highly scattering nature of such tissues complicate the use of the technique. A CARS microscopy approach is presented that overcomes the challenges of imaging myelinated tissue to achieve chemically and orientationally sensitive high-resolution images.

Indexed as

Myelin SheathAnimalsEquipment DesignImage Processing, Computer-AssistedLipidsMiceMice, Inbred C57BLMicroscopySpectrum Analysis, RamanSpinal CordLipidscoherent anti-Stokes Raman scatteringdispersionmyelinnonlinear opticspolarizationRaman scattering

Identifiers

PMID31007003
PMCPMC6990057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.