Evidence map›Paper›PMID 31006988›Full record

ArticleObesity (Silver Spring, Md.)2019

The Mediating Role of Brown Fat and Skeletal Muscle Measured by

Borja Martinez-Tellez, Mireia Adelantado-Renau, Francisco M Acosta, Guillermo Sanchez-Delgado, Antonio Martinez-Nicolas, Mariëtte R Boon, Jose M Llamas-Elvira, Vicente Martinez-Vizcaino, Jonatan R Ruiz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Borja Martinez-TellezPromoting Fitness & Health Through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.ORCID 0000-0001-8783-1859
Mireia Adelantado-RenauLIFE Research Group, University Jaume I, Castellon, Spain.ORCID 0000-0001-6124-8876
Francisco M AcostaPromoting Fitness & Health Through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.ORCID 0000-0002-4792-0969
Guillermo Sanchez-DelgadoPromoting Fitness & Health Through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.ORCID 0000-0003-4455-2483
Antonio Martinez-NicolasChronobiology Laboratory, Department of Physiology, College of Biology, Mare Nostrum Campus, University of Murcia, Instituto Universitario de Investgiación e Envegecimiento (IUIE), Instituto Murciano de Investigación Biosanitaria (IMIB)-Arrixaca, Spain.ORCID 0000-0002-8213-3370
Mariëtte R BoonDepartment of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-3247-7538
Jose M Llamas-ElviraNuclear Medicine Service, Virgen de las Nieves University Hospital, Granada, Spain.ORCID 0000-0002-4661-5030
Vicente Martinez-VizcainoHealth and Social Research Center, Castilla-La Mancha University, Cuenca, Spain.
Jonatan R RuizPromoting Fitness & Health Through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.ORCID 0000-0002-7548-7138
Universidad de Granada · ESInstituto Murciano de Investigación Biosanitaria · ESLeiden University Medical Center · NLUniversidad Autónoma de Chile · CLUniversitat Jaume I · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal-ET) and wrist skin temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between Personal-ET and WT (as a proxy of peripheral vasoconstriction/vasodilation).

methodsThe levels of BAT were quantified by cold-induced

resultsThe study found that BAT volume and metabolic activity played a positive and significant role (up to 25.4%) in the association between Personal-ET and WT. In addition, at the coldest temperatures, the participants with lower levels of WT (inducing higher peripheral vasoconstriction) had higher levels of BAT outcomes, whereas in warm temperatures, participants with higher levels of WT (inducing higher peripheral vasodilation) had lower levels of BAT outcomes. The study did not find any mediating role of skeletal muscle activity.

conclusionsBAT volume and metabolic activity play a role in the relationship between Personal-ET and WT. Moreover, the data suggest that there are two distinct phenotypes: individuals who respond better to the cold, both through nonshivering thermogenesis and peripheral vasoconstriction, and individuals who respond better to the heat.

Indexed as

Adipose Tissue, BrownAdolescentAdultFemaleFluorodeoxyglucose F18HumansMaleMuscle, SkeletalThermogenesisYoung AdultFluorodeoxyglucose F18

Identifiers

PMID31006988
PMCPMC6594074
OpenAlexW2940478045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.