Evidence map›Paper›PMID 31006987›Full record

ArticleCancer medicine2019

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma.

Brandon J Diessner, Tracy A Marko, Ruth M Scott, Andrea L Eckert, Kathleen M Stuebner, Ann E Hohenhaus, Kim A Selting, David A Largaespada, Jaime F Modiano, Logan G Spector

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. S100A4 mRNA-protein relationship uncovered by measurement noise reduction.Journal of molecular medicine (Berlin, Germany) · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Brandon J DiessnerDivision of Pediatric Epidemiology and Clinical Research, School of Medicine, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-3725-3410
Tracy A MarkoMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Ruth M ScottDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.
Andrea L EckertDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.
Kathleen M StuebnerDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota.
Ann E HohenhausAnimal Medical Center, Bobst Hospital, New York, New York.
Kim A SeltingVeterinary Medical Teaching Hospital, University of Missouri, Columbia, Missouri.
David A LargaespadaDepartment of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, Minnesota.
Jaime F ModianoMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Logan G SpectorDivision of Pediatric Epidemiology and Clinical Research, School of Medicine, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · USThe Schwarzman Animal Medical Center · USVeterinary Medical Teaching Hospital · US

Funding

Musculoskeletal Training GrantT32AR050938 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CLOHISY, DENIS R · 2004 to 2020
$3.0M
(PQ3) Modulation of Osteosarcoma Biology by Inflammation and Immunity Defined through a ComparativeApproachR21CA208529 · NCI · UNIVERSITY OF MINNESOTA · PI MODIANO, JAIME F. · 2016 to 2017
$365k
NCI NIH HHS R21 CA208529NIAMS NIH HHS T32 AR050938
6 · The paper itself

Abstract

backgroundCanine osteosarcoma (OS) is a relevant spontaneous model for human OS. Identifying similarities in clinical characteristics associated with metastasis at diagnosis in both species may substantiate research aimed at using canine OS as a model for identifying mechanisms driving distant spread in the human disease.

methodsThis retrospective study included dog OS cases from three academic veterinary hospitals and human OS cases from the Surveillance, Epidemiology, and End Results program. Associations between clinical factors and metastasis at diagnosis were estimated using logistic regression models.

resultsIn humans, those with trunk tumors had higher odds of metastasis at diagnosis compared to those with lower limb tumors (OR = 2.38, 95% CI: 1.51, 3.69). A similar observation was seen in dogs with trunk tumors compared to dogs with forelimb tumors (OR = 3.28, 95% CI 1.36, 7.50). Other associations were observed in humans but not in dogs. Humans aged 20-29 years had lower odds of metastasis at diagnosis compared to those aged 10-14 years (OR = 0.67, 95% CI: 0.47, 0.96); every 1-cm increase in tumor size was associated with a 6% increase in the odds of metastasis at diagnosis (95% CI: 1.04, 1.08); compared to those with a white, non-Hispanic race, higher odds were observed among those with a black, non-Hispanic race (OR: 1.51, 95% CI: 1.04, 2.16), and those with a Hispanic origin (OR 1.35, 95% CI: 1.00, 1.81).

conclusionA common mechanism may be driving trunk tumors to progress to detectable metastasis prior to diagnosis in both species.

Indexed as

AnimalsBone NeoplasmsDog DiseasesDogsFemaleHumansMaleNeoplasm MetastasisNeoplasm StagingOsteosarcomaRisk FactorsSEER ProgramTumor Burdendoghumanmetastasisosteosarcoma

Identifiers

PMID31006987
PMCPMC6558582
OpenAlexW2940611073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.