ArticleAmerican journal of clinical pathology2019
Comparison of Minimally Invasive Tissue Sampling With Conventional Autopsy to Detect Pulmonary Pathology Among Respiratory Deaths in a Resource-Limited Setting.
Article in American journal of clinical pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Pooled it
- Cause-specific mortality of children younger than 5 years in communities receiving biannual mass azithromycin treatment in Niger: verbal autopsy results from a cluster-randomised controlled trial.The Lancet. Global health · 2020Trial
- Exploring minimally invasive tissue sampling as an alternative to conventional autopsy in neonatal deaths.Forensic science, medicine, and pathology · 2026Observational
- Accelerating Proficiency in Minimally Invasive Autopsy for Infectious Disease Diagnosis and Research: A Strategic Framework.Revista da Sociedade Brasileira de Medicina Tropical · 2026Observational
- Diagnostic performance of minimally invasive autopsy in a respiratory ICU: A retrospective analysis.Lung India : official organ of Indian Chest Society · 2026Article
- Diagnostic accuracy of a simplified minimally invasive tissue sampling protocol for stillbirths in low-resource settings.BMJ global health · 2025Article
- Using Minimally Invasive Tissue Sampling and Determination of Cause of Death to Establish Etiologies of Community Respiratory Deaths Among Zambian Infants and Children.Journal of the Pediatric Infectious Diseases Society · 2025Article
- Article
- Postmortem minimally invasive tissue sampling in communities: exploring perceptions of families, funeral workers, religious and community leaders and healthcare providers from Pakistan.BMC health services research · 2023Article
- Minimally invasive autopsies for the investigation of pulmonary pathology of COVID-19-experiences of a longitudinal series of 92 patients.Virchows Archiv : an international journal of pathology · 2023Article
- Building Perinatal Pathology Research Capacity in Sub-Saharan Africa.Frontiers in medicine · 2022Article
- Effect of Time Since Death on Multipathogen Molecular Test Results of Postmortem Specimens Collected Using Minimally Invasive Tissue Sampling Techniques.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Histopathology Is Key to Interpreting Multiplex Molecular Test Results From Postmortem Minimally Invasive Tissue Samples.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Guidance for Systematic Integration of Undernutrition in Attributing Cause of Death in Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- The evolution of minimally invasive tissue sampling in postmortem examination: a narrative review.Global health action · 2020Review
Corrections and comments
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Authors and funding
24 authors at 8 institutions in 2 countries.
Funding
Abstract
objectivesWe compared minimally invasive tissue sampling (MITS) with conventional autopsy (CA) in detection of respiratory pathology/pathogens among Kenyan children younger than 5 years who were hospitalized with respiratory disease and died during hospitalization.
methodsPulmonary MITS guided by anatomic landmarks was followed by CA. Lung tissues were triaged for histology and molecular testing using TaqMan Array Cards (TACs). MITS and CA results were compared for adequacy and concordance.
resultsAdequate pulmonary tissue was obtained by MITS from 54 (84%) of 64 respiratory deaths. Comparing MITS to CA, full histologic diagnostic concordance was present in 23 (36%) cases and partial concordance in 19 (30%), an overall 66% concordance rate. Pathogen detection using TACs had full concordance in 27 (42%) and partial concordance in 24 (38%) cases investigated, an overall 80% concordance rate.
conclusionsMITS is a viable alternative to CA in respiratory deaths in resource-limited settings, especially if combined with ancillary tests to optimize diagnostic accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.