ArticleThe Journal of nutrition2019
Inflammation and Stress Biomarkers Mediate the Association between Household Food Insecurity and Insulin Resistance among Latinos with Type 2 Diabetes.
Article in The Journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01578096 (Stress Management Among Latinos With Type 2 Diabetes Mellitus), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress Management Among Latinos With Type 2 Diabetes Mellitus
Who cites it
27 citing papers in PubMed, 37 citations in OpenAlex.
- Experiences of Hispanic Safety Net Clinic Patients With Diabetes During the COVID-19 Pandemic.The science of diabetes self-management and care · 2022Trial
- Article
- Association Between Food Insecurity and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Cross-Sectional Study in South Korea.Nutrients · 2026Article
- Social Needs and Type 2 Diabetes in Latinos: An Integrative Review.Journal of racial and ethnic health disparities · 2026Review
- From pantry to physiology: A narrative review linking food insecurity to biological dysfunction.Dialogues in health · 2026Review
- Bayesian multilevel analysis of multimorbidity among women in Somalia: prevalence, patterns, and determinants.Archives of public health = Archives belges de sante publique · 2026Article
- C-Reactive Protein in Saliva as a Non-Invasive Marker of Metabolic Syndrome: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Review
- Reframing Food is Medicine as syndemic care: a multidimensional approach to food insecurity.Frontiers in public health · 2026Article
- Biosocial Factors Shaping Perceptions of Disease Risk Among a Community-Based Sample of Sexual and Gender Minority People Living in Toronto During the COVID-19 Pandemic.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Food Insecurity and Clinical Biomarkers of Inflammation among Cancer Survivors in the All of Us Research Program.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Food insecurity and the risk of diabetes: understanding the role of BMI as a mediator and moderator.Obesity (Silver Spring, Md.) · 2025Article
- The Association of Levels of Food Insecurity and Disordered Eating Behaviors Among Youth and Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study.The International journal of eating disorders · 2025Article
- Area Deprivation and Clinical Biomarkers of Inflammation in Cancer Survivors of the National Institutes of Health All of Us Research Program.Cancer medicine · 2025Article
- Inflammation-based Scores in Patients With Pheochromocytoma.The Journal of clinical endocrinology and metabolism · 2025Article
- Review
- Food insecurity, inflammation, and immune function among older US adults: Findings from the health and Retirement study.Brain, behavior, and immunity · 2024Article
- Food insecurity is a risk factor for metabolic dysfunction-associated steatotic liver disease in Latinx children.Pediatric obesity · 2024Article
- Food (in)security in relation to nutrition (in)security in a national cross-sectional sample of Supplemental Nutrition Assistance Program participants: considerations of an emerging construct.The American journal of clinical nutrition · 2024Article
- Cooking with the Community: Addressing Food Insecurity Through Equipment Provision and Professional Instruction.AJPM focus · 2024Article
- Food Insecurity and Pediatric Nonalcoholic Fatty Liver Disease Severity.The Journal of pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundHousehold food insecurity (HFI) is a stressor that is associated with type 2 diabetes (T2D). However, little is known about HFI and the insulin resistance (IR) underlying T2D, and the mechanisms involved.
objectiveWe examined the cross-sectional association between HFI and IR among low-income Latinos with T2D and tested whether inflammation and stress hormones mediated this association.
methodsHFI was measured with the 6-item US Household Food Security Survey module. IR was calculated from fasting plasma blood glucose and serum insulin. Inflammation was indicated by high-sensitivity C-reactive protein (hsCRP), and stress hormones included urinary cortisol, metanephrine, and normetanephrine. To test for an indirect effect of HFI on homeostasis model assessment of IR, a parallel multiple mediation model was run with biological markers that significantly differed between food security status-entered as mediators in the model. We used 95% bias-corrected bootstrap CIs, with 10,000 bootstrap samples, to assess the significance of the indirect effects.
resultsThe 121 participants with T2D were primarily Puerto Rican (85.8%), aged mean = 60.7 y, and 74% were female. Eighty-two (68%) were classified as food insecure. Compared with food-secure individuals, food-insecure individuals had a significantly higher IR [mean difference (Δ) = 7.21, P = 0.001], insulin (Δ = 9.7, P = 0.019), glucose (Δ = 41, P < 0.001), hsCRP (Δ = 0.8, P = 0.008), cortisol (Δ = 21, P = 0.045), and total cholesterol (Δ = 29, P = 0.004). Groups did not differ on other lipids, metanephrine, normetanephrine, or A1c. The mediation model showed a significant direct effect of HFI on hsCRP (P = 0.020) and on cortisol (P = 0.011). There was a direct effect of cortisol (P = 0.013), hsCRP (P = 0.044), and HFI on IR (P = 0.015). The total combined indirect effect of HFI through cortisol and hsCRP indicated partial mediation.
conclusionsAmong Latinos with T2D, HFI is associated with IR partially through inflammation and stress hormones. Interventions to ameliorate HFI and mitigate its effects on inflammation, stress, and IR are warranted. This trial was registered at clinicaltrials.gov as NCT01578096.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.