ArticleCell stem cell2019
Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress.
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Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
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Who cites it
60 citing papers in PubMed, 95 citations in OpenAlex.
- PAX3-SIX2 muscle stem cell heterogeneity drives muscle-specific repair dynamics diversification.Science advances · 2026Article
- Modulatory Activity of Uncaria tomentosa Extract in the Expression of Proteins Involved in the Unfolded Protein Response and Insulin Resistance.Current issues in molecular biology · 2026Article
- The Sirt2-Nur77 axis regulates muscle stem cell quiescence and senescence via epigenetic-metabolic synergy.Cell death & disease · 2026Article
- A latent activated olfactory stem cell state revealed by single-cell transcriptomic and epigenomic profiling.Stem cell reports · 2026Article
- Proximity Ligation Assay to Determine Protein-Protein Interactions in Muscle Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Regulation and function of Pax3 in muscle stem cell heterogeneity and stress response.Journal of muscle research and cell motility · 2025Review
- The Integrated Stress Response Pathway Improves Aged Murine Muscle Stem Cell Activation andbioRxiv : the preprint server for biology · 2025Article
- Single-cell transcriptomics reveals BMP4-BMPR2 signaling promotes radiation resistance in hematopoietic stem cells following injury.Nature communications · 2025Article
- Muscle Stem Cell Microenvironment and Functions in Muscle Regeneration.Biomolecules · 2025Review
- Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.Nature aging · 2025Article
- Metabolic regulation in adult and aging skeletal muscle stem cells.Genes & development · 2025Review
- A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging.Stem cell reports · 2024Article
- Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance.Genes & diseases · 2024Review
- CRIPTO-based micro-heterogeneity of mouse muscle satellite cells enables adaptive response to regenerative microenvironment.Developmental cell · 2023Article
- Gli1 marks a sentinel muscle stem cell population for muscle regeneration.Nature communications · 2023Article
- Radiation induces long-term muscle fibrosis and promotes a fibrotic phenotype in fibro-adipogenic progenitors.Journal of cachexia, sarcopenia and muscle · 2023Article
- The 3D chromatin landscape of rhabdomyosarcoma.NAR cancer · 2023Article
- Generation of a MyoD knock-in reporter mouse line to study muscle stem cell dynamics and heterogeneity.iScience · 2023Article
- Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity.Nature reviews. Molecular cell biology · 2023Review
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Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Annarita ScaramozzaThe Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Dongsu ParkDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Swapna KolluCenter of Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Isabel BeermanDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
Xuefeng SunThe Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Derrick J RossiDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Charles P LinHarvard Stem Cell Institute, Cambridge, MA 02138, USA; Advanced Microscopy Program, Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
David T ScaddenCenter of Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Colin CristLady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, QC H3T 1E2, Canada; Department of Human Genetics, McGill University, Montréal, QC H3A 0C7, Canada.
Andrew S BrackThe Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: andrew.brack@ucsf.edu.
Broad Center · USHarvard University · USBaylor College of Medicine · USCenter for Systems Biology · USHarvard Stem Cell Institute · USJewish General Hospital · CAMassachusetts General Hospital · US
Funding
Microenvironmental control of progenitors in organ dysfunction and repairU01HL100402 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KIM, CARLA F., SCADDEN, DAVID T · 2009 to 2015
$8.5MDefining periosteal skeletal stem cells and novel migration mechanisms in bone regeneration and repair in vivoR01AR072018 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI PARK, DONGSU · 2018 to 2023
$2.1MCharacterization of hematopoietic stem cell (HSC) and progenitor cell aging, identification of candidate age-regulated genes as targets for therapeutic interventionZIAAG000992 · NIA · NATIONAL INSTITUTE ON AGING · PI BEERMAN, ISABEL · 2017 to 2025
$1.7MRole of osteogenic stem cells in bone regeneration and repair in vivoK01AR061434 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI PARK, DONGSU · 2012 to 2016
$659kIntramural NIH HHS Z99 AG999999NHLBI NIH HHS U01 HL100402NIAMS NIH HHS K01 AR061434NIAMS NIH HHS R01 AR072018
Abstract
Stem cell heterogeneity is recognized as functionally relevant for tissue homeostasis and repair. The identity, context dependence, and regulation of skeletal muscle satellite cell (SC) subsets remains poorly understood. We identify a minor subset of Pax7
Indexed as
Adult Stem CellsAnimalsCell DifferentiationCell LineageCell SurvivalClone CellsDNA DamageHumansMiceMice, Inbred C57BLMyxovirus Resistance ProteinsPAX3 Transcription FactorPAX7 Transcription FactorRadiation, IonizingReactive Oxygen SpeciesRegenerationMX1 protein, humanMyxovirus Resistance ProteinsPAX3 protein, humanPAX3 Transcription FactorPAX7 protein, humanPAX7 Transcription FactorReactive Oxygen Speciesclonal expansionmuscle stem cellsMx1Pax3radiationreserve stem cellROSsatellite cellsstresstissue regeneration
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.