ReviewThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2019
The Neuropsychiatry of Parkinson Disease: A Perfect Storm.
Review in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07151378 (Intestinal Levodopa + Entacapone Therapy), which is not on this map. Cited by 87 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intestinal Levodopa + Entacapone Therapy (Lecigon®) to Counteract Dopaminergic Desensitization and Neuropsychiatric Complications in Parkinson's Disease
Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Cognitive behavioral therapy for anxiety and depression symptoms in people of Parkinson's disease: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Pooled it
- Innovating Parkinson's Care: A Randomized Controlled Trial of Telemedicine Depression Treatment.Movement disorders : official journal of the Movement Disorder Society · 2021Trial
- Telephone-based cognitive behavioral therapy for depression in Parkinson disease: A randomized controlled trial.Neurology · 2020Trial
- Meditation and breathwork on anxiety in Parkinson's disease: A pilot randomized controlled trial.Journal of Parkinson's disease · 2026Article
- Parkinson's disease-associated psychosis in a Brazilian sample: prevalence and clinical profile.Arquivos de neuro-psiquiatria · 2026Article
- ZembrinMolecules (Basel, Switzerland) · 2026Article
- Article
- Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases.Brain : a journal of neurology · 2026Article
- The Effects of Tyrosine Hydroxylase Blockade in Mice Lacking the Norepinephrine Transporter (NET-KO Mice).International journal of molecular sciences · 2026Article
- Predictors of Quality of Life in Parkinson's Disease: The Role of Mental Health and Internalized Stigma.Actas espanolas de psiquiatria · 2026Article
- Uncovering the role of c-Fos in the bidirectional relationship between depression/anxiety behaviors and α-synuclein propagation in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Intracisternal IGF-1 gene delivery attenuates early anxiety-like behavior but not dopaminergic neurodegeneration in a 6-OHDA rat model of parkinsonism.Frontiers in aging neuroscience · 2026Article
- Baseline mood and non-motor symptom burden are associated with cognitive progression in Parkinson's disease: an interpretable follow-up cohort analysis with separate neuroimaging, molecular, and digital analyses in independent samples.Frontiers in artificial intelligence · 2026Article
- From Hopelessness to Hope: Addressing Demoralization in Parkinson's Disease.Movement disorders clinical practice · 2026Review
- A transdiagnostic, multi-modal approach to understanding apathy: Methodological and analytical framework.Neuroimage. Reports · 2025Article
- PICALM polymorphisms are associated with susceptibility to parkinson's disease in the Northern Chinese Han population: a case-control study.BMC medical genomics · 2025Article
- Apathy self-awareness and its neural correlates in Parkinson's Disease.NPJ Parkinson's disease · 2025Article
- Serum sirtuin 3 levels and multimodal abnormalities in brain structure and function in Parkinson's disease patients with depression.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Levodopa-Entacapone-Carbidopa Intrajejunal Infusion in Advanced Parkinson's Disease - Interim Analysis of the ELEGANCE Study.Movement disorders clinical practice · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Affective disorders, cognitive decline, and psychosis have long been recognized as common in Parkinson disease (PD), and other psychiatric disorders include impulse control disorders, anxiety symptoms, disorders of sleep and wakefulness, and apathy. Psychiatric aspects of PD are associated with numerous adverse outcomes, yet in spite of this and their frequent occurrence, there is incomplete understanding of epidemiology, presentation, risk factors, neural substrate, and management strategies. Psychiatric features are typically multimorbid, and there is great intra- and interindividual variability in presentation. The hallmark neuropathophysiological changes that occur in PD, plus the association between exposure to dopaminergic medications and certain psychiatric disorders, suggest a neurobiological basis for many psychiatric symptoms, although psychological factors are involved as well. There is evidence that psychiatric disorders in PD are still under-recognized and undertreated and although psychotropic medication use is common, controlled studies demonstrating efficacy and tolerability are largely lacking. Future research on neuropsychiatric complications in PD should be oriented toward determining modifiable correlates or risk factors and establishing efficacious and well-tolerated treatment strategies.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.