ArticleThe Journal of international medical research2019
Aberrant functional connectivity density in patients with treatment-refractory obsessive-compulsive disorder: a pilot study.
Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Functional connectivity density alterations in obsessive-compulsive disorder are associated with neurotransmitter and genetic profiles.Translational psychiatry · 2026Article
- Error-Related Brain Potentials as Biomarkers of Pathology Severity and Treatment Resistance in Patients With Obsessive-Compulsive Disorder.Depression and anxiety · 2026Article
- Neural correlates of distance-related functional reorganization in obsessive compulsive disorder.Journal of psychiatry & neuroscience : JPN · 2026Article
- Obsessive-compulsive disorder and temporal lobe porencephaly: a case report.BMC psychiatry · 2025Article
- Treating refractory obsessive compulsive disorder with cathodal transcranial direct current stimulation over the supplementary motor area: a large multisite randomized sham-controlled double-blind study.Frontiers in psychiatry · 2024Article
- Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary Insomnia.Neuropsychiatric disease and treatment · 2022Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFunctional connectivity (FC) is altered in patients with obsessive-compulsive disorder (OCD). Most previous studies have focused on the strength of FC in patients with OCD; few have examined the number of functional connections in these patients. The number of functional connections is an important index for assessing aberrant FC. In the present study, we used FC density (FCD) mapping to explore alterations in the number of functional connections in patients with treatment-refractory OCD (TROCD) using the FCD index.
methodsTwenty patients with TROCD and 20 patients with OCD in clinical remission were enrolled in the study. Global FCD (gFCD) was adopted to compare the differences between the two groups of patients.
resultsThe gFCD in the left middle temporal gyrus was lower in the patients with TROCD than in those with remitted OCD, suggesting that decreased information processing ability may play a significant role in TROCD.
conclusionThe left middle temporal gyrus is a key component of the emotional processing circuit and attentional processing circuit. Decreased information processing ability in this brain region may play a significant role in TROCD; however, further well-designed follow-up studies are needed to support this hypothesis.
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