Evidence map›Paper›PMID 31006141›Full record

ArticleClinical transplantation2019

Factors predicting kidney delayed graft function among recipients of simultaneous liver-kidney transplantation: A single-center experience.

Islam M Korayem, Vatche G Agopian, Keri E Lunsford, Hans A Gritsch, Jeffrey L Veale, Gerald S Lipshutz, Hasan Yersiz, Coney L Serrone, Fady M Kaldas, Douglas G Farmer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Islam M KorayemDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Vatche G AgopianDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Keri E LunsfordSherrie and Alan Conover Center for Liver Disease and Transplantation, J.C. Walter Jr Transplant Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas.
Hans A GritschDepartment of Urology, David Geffen School of Medicine, University of California, Los Angeles, California.
Jeffrey L VealeDepartment of Urology, David Geffen School of Medicine, University of California, Los Angeles, California.
Gerald S LipshutzDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Hasan YersizDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Coney L SerroneDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Fady M KaldasDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.ORCID 0000-0002-4888-3979
Douglas G FarmerDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Suphamai BunnapradistDivision of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California.
Gabriel M DanovitchDivision of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California.
Ronald W BusuttilDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Ali ZarrinparDivision of Transplantation and Hepatobiliary Surgery, University of Florida, Gainesville, Florida.ORCID 0000-0002-6812-1816
University of California, Los Angeles · USCornell University · USUniversity of Florida · US

Funding

The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient FutilityK08DK118187 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI LUNSFORD, KERI ELIZABETH · 2019 to 2023
$1.1M
Ischemia-reperfusion injury in liver transplantationK08DK113244 · NIDDK · UNIVERSITY OF FLORIDA · PI ZARRINPAR, ALI · 2017 to 2021
$814k
NCATS NIH HHS KL2 TR001882NIDDK NIH HHS K08 DK113244NIDDK NIH HHS K08 DK118187
6 · The paper itself

Abstract

backgroundKidney delayed graft function (kDGF) remains a challenging problem following simultaneous liver and kidney transplantation (SLKT) with a reported incidence up to 40%. Given the scarcity of renal allografts, it is crucial to minimize the development of kDGF among SLKT recipients to improve patient and graft outcomes. We sought to assess the role of preoperative recipient and donor/graft factors on developing kDGF among recipients of SLKT.

methodsA retrospective review of 194 patients who received SLKT in the period from January 2004 to March 2017 in a single center was performed to assess the effect of preoperative factors on the development of kDGF.

resultsKidney delayed graft function was observed in 95 patients (49%). Multivariate analysis revealed that donor history of hypertension, cold static preservation of kidney grafts [versus using hypothermic pulsatile machine perfusion (HPMP)], donor final creatinine, physiologic MELD, and duration of delay of kidney transplantation after liver transplantation were significant independent predictors for kDGF. kDGF is associated with worse graft function and patient and graft survival.

conclusionsKidney delayed graft function has detrimental effects on graft function and graft survival. Understanding the risks and combining careful perioperative patient management, proper recipient selection and donor matching, and graft preservation using HPMP would decrease kDGF among SLKT recipients.

Indexed as

Cold TemperatureGraft SurvivalAdultDelayed Graft FunctionFemaleFollow-Up StudiesHumansIncidenceKidney TransplantationLiver TransplantationMaleMiddle AgedOrgan PreservationPerfusionPredictive Value of TestsProspective Studiesdelayed graft function (DGF)dysfunctionkidney (allograft) functionorgan perfusion and preservation

Identifiers

PMID31006141
PMCPMC6653637
OpenAlexW2939726581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.