Evidence map›Paper›PMID 31006072›Full record

ArticleBrain structure & function2019

Neurite orientation dispersion and density imaging of mouse brain microstructure.

Nian Wang, Jieying Zhang, Gary Cofer, Yi Qi, Robert J Anderson, Leonard E White, G Allan Johnson

Open access · greenAbstract read
In one paragraph

Article in Brain structure & function, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Brain microstructure mediates the relationship between Alzheimer's proteinopathies and memory.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Diffusion MRI reveals amyloid plaque-associated cellular signatures through spatial transcriptomic integration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  19. Changes in Cortical Microstructure of the Human Brain Resulting from Long-Term Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Nian WangCenter for In Vivo Microscopy, Department of Radiology, Duke Medical Center, Duke University, 3302, Durham, NC, 27710, USA. nian.wang@duke.edu.ORCID http://orcid.org/0000-0001-6547-8580
Jieying ZhangDepartment of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.
Gary CoferCenter for In Vivo Microscopy, Department of Radiology, Duke Medical Center, Duke University, 3302, Durham, NC, 27710, USA.
Yi QiCenter for In Vivo Microscopy, Department of Radiology, Duke Medical Center, Duke University, 3302, Durham, NC, 27710, USA.
Robert J AndersonCenter for In Vivo Microscopy, Department of Radiology, Duke Medical Center, Duke University, 3302, Durham, NC, 27710, USA.
Leonard E WhiteDepartment of Neurology, Duke University School of Medicine, Durham, NC, USA.
G Allan JohnsonCenter for In Vivo Microscopy, Department of Radiology, Duke Medical Center, Duke University, 3302, Durham, NC, 27710, USA. gjohnson@duke.edu.
Duke Medical Center · USDuke University · USTsinghua University · CN

Funding

INTEGRATED CENTER FOR IN VIVO MICROSCOPYP41EB015897 · NIBIB · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2017
$7.4M
Waxholm Space for Rodent NeuroinformaticsR01NS096720 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C · 2016 to 2019
$2.4M
Agilent Direct Drive 9.4T MRS/MRI ConsoleS10OD010683 · OD · DUKE UNIVERSITY · PI JOHNSON, GEORGE ALLAN · 2012 to 2012
$597k
National Institute of Biomedical Imaging and Bioengineering 1S10OD010683-01National Institute of Biomedical Imaging and Bioengineering P41 EB015897National Institute of Neurological Disorders and Stroke 1R01NS096720-01A1NIBIB NIH HHS P41 EB015897NIH HHS S10 OD010683NINDS NIH HHS R01 NS096720
6 · The paper itself

Abstract

Advanced biophysical models like neurite orientation dispersion and density imaging (NODDI) have been developed to estimate the microstructural complexity of voxels enriched in dendrites and axons for both in vivo and ex vivo studies. NODDI metrics derived from high spatial and angular resolution diffusion MRI using the fixed mouse brain as a reference template have not yet been reported due in part to the extremely long scan time required. In this study, we modified the three-dimensional diffusion-weighted spin-echo pulse sequence for multi-shell and undersampling acquisition to reduce the scan time. This allowed us to acquire several exhaustive datasets that would otherwise not be attainable. NODDI metrics were derived from a complex 8-shell diffusion (1000-8000 s/mm

Indexed as

Brain MappingImage Processing, Computer-AssistedAnimalsBrainDendritesDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingMaleMice, Inbred C57BLNeuritesCompressed sensingCuprizoneDemyelinationDiffusion MRINeurite densityNODDI

Identifiers

PMID31006072
PMCPMC6565502
OpenAlexW2937898654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.