ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020
Renal handling of zinc in chronic kidney disease patients and the role of circulating zinc levels in renal function decline.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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50 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.PLoS genetics · 2025Pooled it
- A Narrative Review of Zinc Deficiency-Associated Anemia.Hematology reports · 2026Review
- Zinc deficiency and antihypertensive treatment intensity in patients initiating dialysis: a cross-sectional analysis from the Jikei hemodialysis and peritoneal dialysis study (JHPS).Clinical and experimental nephrology · 2026Article
- The relationship between serum zinc level and prognosis of non-dialysis CKD patients.BMC nephrology · 2026Article
- Targeting intestinal zinc transporters: a novel therapeutic approach for zinc deficiency in chronic kidney disease.Kidney research and clinical practice · 2026Article
- Associations of 24-h urinary excretion of heavy metals and trace elements with estimated glomerular filtration rate and chronic kidney disease.Scientific reports · 2026Article
- Urinary heavy metal and trace element mixtures in chronic kidney disease: associations and implications for potential reverse causality.Frontiers in toxicology · 2026Article
- Zinc deficiency contributes to blunted myogenesis in chronic kidney disease.American journal of physiology. Cell physiology · 2026Article
- Zinc Deficiency Aggravates High-Fat Diet-Induced Renal Injury by Regulating Oxidative Stress and Inflammation via the Nrf2/HO-1 Pathway.Biological trace element research · 2026Article
- Zinc, type 2 diabetes, diabetic kidney disease: focus on hypoxia.Frontiers in endocrinology · 2026Review
- Serum zinc level is associated with aortic arch calcification in incident dialysis patients.Journal of nephrology · 2025Article
- Type 2 diabetes mellitus and zinc dysregulation: From basic and epidemiological evidence to interventions.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Review
- Article
- Zinc Deficiency in Chronic Kidney Disease and Hemodialysis: Insights from Basic Research to Clinical Implications.Nutrients · 2025Review
- Managing Hypertension in Chronic Kidney Disease: The Role of Diet and Guideline Recommendations.Journal of clinical medicine · 2025Review
- Zinc deficiency predicts new-onset diabetic kidney disease in type 2 diabetes: a retrospective cohort study.Frontiers in nutrition · 2025Article
- The interaction between the gene SOD1 rs2070424 and the plasma zinc/copper ratio predicts renal function impairment.Frontiers in nutrition · 2025Article
- Zinc deficiency as a contributor to acute kidney injury in patients with chronic kidney disease: a propensity score-matched retrospective analysis.Frontiers in nutrition · 2025Article
- Role of urinary trace elements in diabetic kidney disease: a cross-sectional analysis.BMJ open diabetes research & care · 2024Article
- Effects of zinc in podocytes and cortical collecting duct in vitro and Dahl salt-sensitive rats in vivo.The Journal of biological chemistry · 2024Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundZinc deficiency is commonly encountered in chronic kidney disease (CKD). The aims of this study were to assess whether zinc deficiency was related to increased renal excretion of zinc and to the progression of CKD.
methodsPlasma and 24-h urinary zinc levels, urinary electrolytes and uromodulin were measured in 108 CKD patients and 81 individuals without CKD. Serum creatinine values were collected for 3 years to calculate the yearly change in estimated glomerular filtration rate (eGFR). Multivariable regression analysis was performed to assess the association between baseline zinc levels and yearly change in eGFR.
resultsCKD patients had lower circulating zinc levels and higher 24-h urinary zinc excretion than non-CKD participants (612.4 ± 425.9 versus 479.2 ± 293.0 µg/day; P = 0.02). Fractional excretion (FE) of zinc was higher and it significantly increased at more advanced CKD stages. Zinc FE was correlated negatively with 24-h urinary uromodulin excretion (r=-0.29; P < 0.01). Lower baseline plasma zinc levels were associated with a faster yearly decline of renal function in age, gender, diabetes and hypertension adjusted models, but this relationship was no longer significant when baseline eGFR or proteinuria were included.
conclusionsZinc levels are lower in CKD, and not compensated by reduced renal zinc excretion. The inverse association between urinary zinc excretion and uromodulin possibly points to an impaired tubular activity, which could partly account for zinc imbalance in CKD. These data suggest that zinc status is associated with renal function decline, but further studies elucidating the underlying mechanisms and the potential role of zinc supplements in CKD are needed.
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