ArticleInternational journal of epidemiology2019
Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study.
Article in International journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease.American journal of respiratory and critical care medicine · 2023Pooled it
- Genetically predicted Circulating inflammatory proteins mediate the association between plasma lipidome and kidney stones: A Mendelian randomization study.Urolithiasis · 2025Article
- Mediating role of basophils in the triacylglycerol-asthma link: a Mendelian randomization study.3 Biotech · 2025Article
- Machine learning for detection of diffusion abnormalities-related respiratory changes among normal, overweight, and obese individuals based on BMI and pulmonary ventilation parameters: an observational study.BMC medical informatics and decision making · 2025Observational
- Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Trends in disease burden and risk factors of asthma from 1990 to 2019 in Belt and Road Initiative countries: evidence from the Global Burden of Disease Study 2019.Annals of medicine · 2024Article
- Factors associated with having uncontrolled asthma in rural Appalachia.The Journal of asthma : official journal of the Association for the Care of Asthma · 2024Article
- Association of psoriasis with allergic multimorbidity of asthma, rhinitis, and eczema among adolescents: a cross-sectional study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Article
- The association between waist circumference and adult asthma attack using nationally representative samples.BMC public health · 2024Article
- Association between advanced lung cancer inflammation index and unstable asthma: a population-based study from the NHANES 2007-2018.Frontiers in nutrition · 2024Article
- The associations between asthma and common comorbidities: a comprehensive Mendelian randomization study.Frontiers in medicine · 2023Article
- Obesity and risk for respiratory diseases: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Causal risk factors for asthma in Mendelian randomization studies: A systematic review and meta-analysis.Clinical and translational allergy · 2022Review
- Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma.Communications biology · 2022Article
- Association of weight change patterns across adulthood with incident asthma: a retrospective cohort study.Scientific reports · 2022Article
- Burden of rare coding variants reveals genetic heterogeneity between obese and non-obese asthma patients in the African American population.Respiratory research · 2022Article
- Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data.PLoS genetics · 2022Article
- Using Mendelian randomization as the cornerstone for causal inference in epidemiology.Environmental science and pollution research international · 2022Article
- Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity.Frontiers in genetics · 2022Review
- The bidirectional association between wheezing and obesity during adolescence and the beginning of adulthood in the 1993 birth cohort, Pelotas, Brazil.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObservational associations between asthma and obesity are well established, but inferring causality is challenging. We leveraged publicly available summary statistics to ascertain the causal direction between asthma and obesity via Mendelian randomization in European-ancestry adults.
methodsWe performed two-sample bi-directional Mendelian randomization analysis using publicly available genome-wide association studies summary statistics. Single nucleotide polymorphisms associated with asthma and body mass index at genome-wide significance were combined using a fixed effect meta-analysis in each direction. An extensive sensitivity analysis was considered.
resultsThere was evidence in support of increasing causal effect of body mass index on risk of asthma (odds ratio 1.18 per unit increase, 95% confidence interval (CI) (1.11, 1.25), P = 2 × 10-8. No significant causal effect of asthma on adult body mass index was observed [estimate -0.004, 95% CI (-0.018, 0.009), P = 0.553].
conclusionsOur results confirmed that in European-ancestry populations, adult body mass index is likely to be causally linked to the risk of asthma; yet the effect of asthma on body mass index is small, if present at all.
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Registered trials
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