Evidence map›Paper›PMID 31005753›Full record

Trial reportBlood cells, molecules & diseases2019

Screening umbilical cord blood for congenital Iron deficiency.

Brianna C MacQueen, Robert D Christensen, Vickie L Baer, Diane M Ward, Gregory L Snow

Open access · greenAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Blood cells, molecules & diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Impact and interactions between risk factors on the iron status of at-risk neonates.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  9. Review
  10. Article
  11. Reconciling markedly discordant values of serum ferritin versus reticulocyte hemoglobin content.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brianna C MacQueenDepartment of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA. Electronic address: brianna.macqueen@hsc.utah.edu.
Robert D ChristensenDepartment of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA; Women and Newborn's Clinical Program, Intermountain Healthcare, Murray, UT, USA; Department of Pediatrics, Division of Hematology/Oncology, University of Utah Health, Salt Lake City, UT, USA.
Vickie L BaerWomen and Newborn's Clinical Program, Intermountain Healthcare, Murray, UT, USA.
Diane M WardDepartment of Pathology, University of Utah Health, Salt Lake City, UT, USA.
Gregory L SnowThe Statistical Data Center, Intermountain Healthcare, Salt Lake City, UT, USA.
University of Utah · USIntermountain Healthcare · US

Funding

Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
NIDDK NIH HHS U54 DK110858
6 · The paper itself

Abstract

objectivesSmall for gestational age infants (SGA), infants of diabetic mothers (IDM), and very low birth weight infants (VLBW) are at risk for congenital iron deficiency. We evaluated the iron status of SGA, IDM, and VLBW neonates at birth and sought mechanistic explanations in those with iron deficiency.

methodsThis was a prospective study. If congenital iron deficiency was present, maternal iron studies were obtained. When neonates were two weeks old, their iron status was reevaluated.

resultsSixteen of 180 neonates screened were iron deficient at birth. The Body Mass Index of the 16 mothers was high. These mothers often had mild iron deficiency and measurable hepcidin levels. Two weeks after birth, neonates had improved iron measurements.

conclusionsAmong SGA, IDM, and VLBW neonates, maternal obesity is a risk factor for congenital iron deficiency. We speculate that elevated hepcidin levels in obese pregnant women impede iron absorption and interfere with transplacental iron transfer.

Indexed as

Fetal BloodAnemia, Iron-DeficiencyBiomarkersFemaleHematologic TestsHumansInfant, NewbornInfant, Small for Gestational AgeIronPregnancyProspective StudiesBiomarkersIronCongenitalIron deficiencyNewborn

Identifiers

PMID31005753
PMCPMC6573027
OpenAlexW2937419538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.