ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2019
Frailty trajectories in adult lung transplantation: A cohort study.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Change in frailty status in the 12 months following solid organ transplantation: a systematic review and meta-analysis.Age and ageing · 2025Pooled it
- Prevalence and assessment of frailty in interstitial lung disease - a systematic review and meta-analysis.Chronic respiratory diseasePooled it
- Discharge frailty following lung transplantation.Clinical transplantation · 2019Trial
- Lung transplantation outcomes in candidates aged ≥ 70 years old: A 10-year single center experience.JHLT open · 2026Article
- Post-transplant trajectories of the CRP-to-albumin ratio identify a late-emerging high-risk phenotype in interstitial lung disease.BMC pulmonary medicine · 2026Observational
- Frailty in Pulmonary Arterial Hypertension: A Cohort Study.Annals of the American Thoracic Society · 2026Article
- Peri-transplant frailty changes impact survival in interstitial lung diseases.ERJ open research · 2026Article
- Frailty in Pulmonary Hypertension: A Multidimensional Comorbidity.Annals of the American Thoracic Society · 2025Review
- Analysis of frailty change trajectories and its risk factors in patients with gastrointestinal tumor surgery: a prospective observational longitudinal study.World journal of surgical oncology · 2025Observational
- Rehabilitation for Physical Frailty in Lung Transplant Candidates: A Systematic Review.Cardiopulmonary physical therapy journal · 2025Article
- Impact of Inadequate Nutrition in Lung Transplant Recovery: A Meta-Analysis.Iranian journal of public health · 2025Review
- Clinical Application of Frailty in the Evaluation of Solid Organ Transplant Patients.Current transplantation reports · 2024Article
- Rehabilitation interventions to modify physical frailty in adults before lung transplantation: a systematic review protocol.BMJ open · 2024Article
- ERS International Congress 2023: highlights from the Thoracic Surgery and Lung Transplantation Assembly.ERJ open research · 2024Article
- Poor functional status at the time of waitlist for pediatric lung transplant is associated with worse pretransplant outcomes.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Development of the Lung Transplant Frailty Scale (LT-FS).The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Subphenotypes of frailty in lung transplant candidates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Frailty and solid-organ transplant candidates: a scoping review.BMC geriatrics · 2022Article
- Relationship of Exercise Capacity, Physical Function, and Frailty Measures With Clinical Outcomes and Healthcare Utilization in Lung Transplantation: A Scoping Review.Transplantation direct · 2022Article
- The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.Current transplantation reports · 2022Article
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Funding
Abstract
backgroundFrailty is common in adults with advanced lung disease and is associated with death before and after lung transplantation. We aimed to determine whether frailty changes from before to after the lung transplant.
methodsIn a single-center, prospective cohort study among adults undergoing lung transplantation from 2010 to 2017, we assessed frailty by the Short Physical Performance Battery (SPPB; higher scores reflect less frailty) and Fried Frailty Phenotype (FFP; higher scores reflect greater frailty) before and repeatedly up to 36 months after transplant. We tested for changes in frailty scores over time using segmented mixed effects models, adjusting for age, sex, and diagnosis. We quantified the proportion of subjects transitioning between frailty states (frail vs not frail) from before to after the transplant.
resultsIn 246 subjects, changes in frailty occurred within the first 6 post-operative months and remained stable thereafter. The overall change in frailty was attributable to improvements among those subjects who were frail before transplant. They experienced a 5.1-point improvement in SPPB (95% confidence interval [CI] 4.6-5.7) and a 1.8-point improvement in FFP (95% CI -2.1 to -1.6) during the early period. Frailty by SPPB and FFP did not change in those who were not frail before transplant. Approximately 84% of survivors who were frail before transplant became not frail after transplant.
conclusionsPre-operative frailty resolves in many patients after lung transplantation. Because a large proportion of frailty may be attributable to advanced lung disease, frailty alone should not be an absolute contraindication to transplantation.
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